217 -4 (78) 2025 - Jalilova A.S. - MODERN LABORATORY CHARACTERISTICS OF INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS AND CYTOMEGALOVIRUS

MODERN LABORATORY CHARACTERISTICS OF INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS AND CYTOMEGALOVIRUS

Jalilova A.S. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Infectious mononucleosis (IM), primarily caused by Epstein-Barr virus (EBV) and less frequently by cytomegalovirus (CMV), remains a significant clinical and diagnostic challenge, especially in pediatric populations. This study aims to highlight the modern laboratory features that distinguish IM caused by EBV and CMV, emphasizing diagnostic accuracy and early differentiation. A combined retrospective and prospective analysis was conducted on 320 children with IM. Clinical and laboratory markers were evaluated, including hematological parameters, enzyme-linked immunosorbent assay (ELISA) for viral antigens, and polymerase chain reaction (PCR) for viral DNA detection. The presence of atypical mononuclear cells, elevated liver enzymes, and specific viral serology patterns allowed for reliable differentiation between EBV and CMV etiologies. EBV-related IM showed a higher incidence of lymphocytosis, atypical monocytes, and splenomegaly, whereas CMV-related cases were more frequently associated with mild or subclinical presentations and less pronounced hematological abnormalities

Key words: IM, CMV-infections, PCR, Elisa, immunological test, Epstein-Barr virus

First page

1198

Last page

1201

For citation:Jalilova A.S. - MODERN LABORATORY CHARACTERISTICS OF INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN-BARR VIRUS AND CYTOMEGALOVIRUS//New Day in Medicine 4(78)2025 1198-1201 https://newdayworldmedicine.com/en/new_day_medicine/4-78-2025

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