6 -1 (39) 2022 — Axrarov X.X. — INTESTINAL MICROBIOTE AND METABOLISM OF GALL ACIDS

INTESTINAL MICROBIOTE AND METABOLISM OF GALL ACIDS

Axrarov X.X. Tashkent Pediatric Medical Institute

Resume

The gut microbiota regulates the synthesis and metabolism of bile acids. An imbalance in the intestinal microbiome leads to a disruption in the synthesis of bile acid. Disruption of the pool of bile acids is accompanied by an imbalance of the intestinal microbiota, which increases the disruption of the synthesis and metabolism of bile acids, contributes to the development of cholestatic liver diseases and their transition to cirrhosis. Violations of the complex mechanism of the relationship between the intestinal microbiome and the metabolism of bile acids also affect the development of liver and intestinal diseases. More and more studies are devoted to the problem of the “liver-intestinal axis” in the pathogenesis of liver and intestinal diseases.

Key words: intestinal microbiota, bile acids, bile acid metabolism.

First page

32

Last page

37

For citation: Axrarov X.X. INTESTINAL MICROBIOTE AND METABOLISM OF GALL ACIDS //New Day in Medicine 1(39)2022 32-37 https://cutt.ly/BU7JcLa

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