19 -5 (79) 2025 - Feruza M.K. - RESULTS OF IMMUNOLOGICAL STUDIES IN A GROUP OF CHILDREN WITH HELICOBACTER PYLORI ASSOCIATED GASTRODUODENAL PATHOLOGY

RESULTS OF IMMUNOLOGICAL STUDIES IN A GROUP OF CHILDREN WITH HELICOBACTER PYLORI ASSOCIATED GASTRODUODENAL PATHOLOGY

Feruza M.K. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

On a global scale, special attention is paid to research to determine the clinical and immunological aspects of the prevalence and development of gastroduodenal diseases in children around the world, and to improve therapeutic measures. In this regard, elucidation of the origin and risk factors for the development of gastroduodenal pathology in children, isolation of the causative agent Helicobacter pylori, determination of various biological features, elucidation of the state of biochemical and immunological indicators of the disease, identification of important immunogenetic markers of pathology, mechanisms of clinical manifestations of severe types remains a priority task of scientific research. Patients and methods. The aim of the study was to include children with gastroduodenal pathology associated and unrelated to CP from the entire cohort of examined children in the study. We studied the mediators of the immune response using the example of IL-1ß and TNF-α in 165 sick children and almost healthy children aged 15 years, who made up a control group for comparison.H. pylori " + " and X. pylori " - " pathologies of the gastroduodenal zone are divided by age into 2 subgroups. Results: IL-1B levels in the control group of children aged 7-14 years were 21.6±0.86 pg/ml compared with 24.2±0.72 pg/ml in children aged 15-18 years. In children aged 15-18 years, 27.4± 0.76 pg/ml.

Keywords: children, gastroduodenitis, peptic ulcer, Helicobacter pylori, immunology, genetics.

First page

95

Last page

97

For citation:Feruza M.K. - RESULTS OF IMMUNOLOGICAL STUDIES IN A GROUP OF CHILDREN WITH HELICOBACTER PYLORI ASSOCIATED GASTRODUODENAL PATHOLOGY//New Day in Medicine 5(79)2025 95-97 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

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