35 -5 (79) 2025 - Muxitdinova K.О., Aleynik V.A. - INFLUENCE OF UNFRACTIONATED AND LOW-MOLECULAR WEIGHT HEPARIN ON CHANGES IN LEUCOCYTE DNA METHYLATION IN WOMEN WITH EARLY PREGNANCY MISCARRIAGE

INFLUENCE OF UNFRACTIONATED AND LOW-MOLECULAR WEIGHT HEPARIN ON CHANGES IN LEUCOCYTE DNA METHYLATION IN WOMEN WITH EARLY PREGNANCY MISCARRIAGE

Muxitdinova K.О. - Andijan State Medical Institute

Aleynik V.A. - Andijan Branch of the Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan

Babich S.M. - Andijan State Medical Institute

Negmatshaeva H.N. - Andijan State Medical Institute

Juraev B.M. - Andijan Branch of the Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan

Resume

The work studied the effect of unfractionated and low-molecular-weight heparin on changes in leukocyte DNA methylation in women with early pregnancy miscarriages. It was concluded that UFH in women with miscarriages without genital infections more effectively reduces the proinflammatory load, which is important for preventing complications associated with hyperinflammation. It helps maintain an anti-inflammatory response, which is important for the balance of the immune system during gestation. It modulates tissue-remodeling processes more effectively, reducing the risk of pathologies associated with excessive MMP activity. It also normalizes epigenetic disorders, which can reduce the risk of long-term complications in the fetus and mother. LMWH demonstrates partial anti-inflammatory efficacy. It is less effective in matrix remodeling, which may be associated with a selective effect on individual links of inflammation. It also has a weak effect on epigenetic markers, maintaining the risk of long-term complications. UFH demonstrates a more pronounced therapeutic potential in pregravid preparation of high-risk women compared to LMWH. UFH is suitable for short-term therapy with an emphasis on epigenetic modulation. LMWH is safer with long-term use, but its effect on DNA methylation is less pronounced.

Keywords: MMP, DNA, UFH

First page

166

Last page

173

For citation:Muxitdinova K.О., Aleynik V.A., Babich S.M., Negmatshaeva H.N., Juraev B.M. - INFLUENCE OF UNFRACTIONATED AND LOW-MOLECULAR WEIGHT HEPARIN ON CHANGES IN LEUCOCYTE DNA METHYLATION IN WOMEN WITH EARLY PREGNANCY MISCARRIAGE//New Day in Medicine 5(79)2025 166-173 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

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