77 -5 (79) 2025 - Usmanova Z.A., Rozikhodjaeva G.A. - THE SIGNIFICANCE OF ZINC LEVELS IN VARIOUS BIOLOGICAL SUBSTRATES IN PATIENTS WITH DIABETES MELLITUS AND DIAGNOSED CAROTID ATHEROSCLEROSIS

THE SIGNIFICANCE OF ZINC LEVELS IN VARIOUS BIOLOGICAL SUBSTRATES IN PATIENTS WITH DIABETES MELLITUS AND DIAGNOSED CAROTID ATHEROSCLEROSIS

Usmanova Z.A. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Rozikhodjaeva G.A. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Sha-Akhmedova L.R. - Under the Administration of the President of the Republic of Uzbekistan at the address: Tashkent, first Central District Clinical Hospital named after Mirzo Ulugbek

Akhmatkhodjaeva D.A. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Plugar V.I. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Fayziyev B.S. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Resume

In patients diagnosed with carotid atherosclerosis, the levels of zinc in hair, atherosclerotic plaque (ASP), and blood serum were studied in groups with and without type 2 diabetes mellitus (T2DM). Correlations between zinc concentrations in these biosubstrates were analyzed. In patients with T2DM, decreased zinc levels were observed in both hair and ASP samples. A positive correlation was also found between zinc levels in blood serum and those in atherosclerotic plaques

Key words: Zinc of the serum, hair, atherosclerotic plaques of carotid artery, carotid atherosclerosis, type 2 diabetes mellitus

First page

393

Last page

397

For citation:Usmanova Z.A., Rozikhodjaeva G.A., Sha-Akhmedova L.R., Akhmatkhodjaeva D.A., Plugar V.I., Fayziyev B.S. - THE SIGNIFICANCE OF ZINC LEVELS IN VARIOUS BIOLOGICAL SUBSTRATES IN PATIENTS WITH DIABETES MELLITUS AND DIAGNOSED CAROTID ATHEROSCLEROSIS//New Day in Medicine 5(79)2025 393-397 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Каримов Ш.И., Юлбарисов А.А., Ахматов А.М. и др. Алгоритм ранней диагностики хронического нарушения мозгового кровообращения с целью определения показаний к вмешательствам на экстракраниальных сосудах головного мозга// Медицинский журнал Узбекистана.- 2024.-№3.-С.114-122.
2. Рогозина Л.А., Симерзин В.В., Щукин Ю.В. и др. Особенности взаимосвязи атеросклеротического поражения сонных артерий и выраженности кардиальной патологии у больных пожилого возраста // Клиническая медицина.-2012.-№1.-С.38-40.
3. Скальная М.Г. Обоснование коррекции элементного дисбаланса у женщин перименопаузального возраста, страдающих обменными заболеваниями // Эстетическая медицина.- 2010.-№ 2.-С.164-169.
4. Сумин А.Н., Безденежных Н.А., Безденежных А.В. и др. Предикторы госпитальных осложнений и длительной госпитализации у пациентов, перенесших коронарное шунтирование: роль свободных жирных кислот и индексов инсулинорезистентности// Байкальский медицинский журнал.-2023. - №2(3). - С. 98-100.
5. Afridi H.I., Kazi T.G., Brabazon D. et al. Comparative metal distribution in scalp hair of Pakistani and Irish referents and diabetes mellitus patients // Clin Chim Acta.-2013.-№16.- P.207-214.
6. Ferdousi S., Mia A.R. Serum levels of copper and zinc in newly diagnosed type-2 diabetic subjects // Mymensingh Med J.-2012.-№21.- P.475–478.
7. Jayawardena R., Ranasinghe P., Galappatthy P. et al. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis // Diabetology & Metabolic Syndrome.-2012.-4:13
8. Kaur B., Henry J. Micronutrient status in type 2 diabetes: a review // Adv Food Nutr Res.-2014.-№71.-P.55-100.
9. Kazi T.G., Afridi H.I., Kazi N. et al. Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients // Biol Trace Elem Res.-2008.-№122.- P.1-18.
10. Miao X., Sun W., Fu Y. et al. Zinc homeostasis in the metabolic syndrome and diabetes // Front Med.-2013.-№7.- P.31-52.

    file

    download