98 -5 (79) 2025 - Usmanova N.Y., Sanoev B.A. - EVALUATION OF HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL CHANGES (ER, PR, SHIK REACTION) IN ENDOMETRIAL HYPERPLASIA IN WOMEN OF LATE REPRODUCTIVE AGE

EVALUATION OF HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL CHANGES (ER, PR, SHIK REACTION) IN ENDOMETRIAL HYPERPLASIA IN WOMEN OF LATE REPRODUCTIVE AGE

Usmanova N.Y. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Sanoev B.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Endometrial hyperplasia in women of late reproductive age is one of the important gynecological problems that negatively affects reproductive health. This condition is often associated with the enlargement of glandular tissues, hormonal imbalances, and a decline in reproductive function. Modern diagnostic methods, including histochemical and immunohistochemical analyses, play a significant role in identifying pathological and molecular changes in the endometrium

Keywords: endometrial hyperplasia; ER; PR; CHIC reaction; infertility

First page

493

Last page

497

For citation:Usmanova N.Y., Sanoev B.A. - EVALUATION OF HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL CHANGES (ER, PR, SHIK REACTION) IN ENDOMETRIAL HYPERPLASIA IN WOMEN OF LATE REPRODUCTIVE AGE//New Day in Medicine 5(79)2025 493-497 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Zain M. et al. Diagnostic role of PAS (Schiff) reaction in identifying atypical hyperplasia of endometrium // J Clin Pathol. – 2020.
2. Sasaki M., et al. Utility of histochemical PAS staining in assessing endometrial structure // Histol Histopathol. – 2018.
3. Aziz S. et al. Estrogen and progesterone receptor expression in endometrial hyperplasia // Gynecol Oncol. – 2022.
4. Bruce J., et al. Progesterone resistance and infertility in endometrial pathology // Reprod Biol Endocrinol. – 2021.
5. Koshiyama M., et al. Expression of ER and PR in endometrial glandular hyperplasia and carcinoma // Int J Gynecol Pathol. – 2019.
6. Park J.Y., et al. Hormone receptor status in pre-malignant endometrial lesions // J Obstet Gynaecol Res. – 2017.
7. Walker D. et al. Estrogen signaling in endometrial carcinogenesis // Cancer Res. – 2020.
8. Bae J., et al. Immunohistochemical analysis of PR and ER in endometrial disease // Diagn Pathol. – 2019.
9. Курбанова Р.Т. Экспрессия рецепторов к стероидным гормонам в гиперпластическом эндометрии // Акушерство и гинекология. – 2021.
10. Мухаметова С.А. Применение PAS-реакции в диагностике гиперплазии эндометрия // Вестник патологии. – 2020.

    file

    download