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  • 118 -5 (79) 2025 - Usmonkulov M., Rabbimova D. - THE ROLE OF INTESTINAL BARRIER DYSFUNCTION IN THE PROGRESSION OF CONGENITAL HEART DEFECTS IN CHILDREN

118 -5 (79) 2025 - Usmonkulov M., Rabbimova D. - THE ROLE OF INTESTINAL BARRIER DYSFUNCTION IN THE PROGRESSION OF CONGENITAL HEART DEFECTS IN CHILDREN

THE ROLE OF INTESTINAL BARRIER DYSFUNCTION IN THE PROGRESSION OF CONGENITAL HEART DEFECTS IN CHILDREN

Usmonkulov M. - Samarkand State Medical University

Rabbimova D. - Samarkand State Medical University

Resume

Congenital heart defects (CHD) are the most common congenital anomalies and a significant factor in morbidity and mortality in pediatric practice. Despite the fact that most clinical approaches focus on cardiovascular complications, evidence is emerging indicating the important role of extracardiac factors, especially involvement of the gastrointestinal tract, in the progression of the disease. In children with CHD, chronic hypoxia, systemic inflammation, and surgical stress contribute to intestinal dysbiosis and disruption of the integrity of the intestinal epithelial barrier. Barrier dysfunction facilitates bacterial translocation, endotoxemia, and systemic immune activation, which increases the risk of perioperative infections, multiple organ failure, and adverse neurodevelopments. Moreover, metabolites produced by the intestinal microbiota, such as short-chain fatty acids and trimethylamine N-oxide (TMAO), can directly affect the function of the cardiovascular system. This review summarizes current data on the pathophysiology of intestinal barrier disorders in CHD, its immunological and metabolic consequences, as well as clinical correlations. A deeper understanding of the mechanisms of the gut–heart axis may contribute to the development of new therapeutic strategies aimed at preserving intestinal barrier function and improving long-term prognosis in this vulnerable group of patients.

Keywords: congenital heart disease, children, microbiota, intestinal barrier

First page

583

Last page

587

For citation:Usmonkulov M., Rabbimova D. - THE ROLE OF INTESTINAL BARRIER DYSFUNCTION IN THE PROGRESSION OF CONGENITAL HEART DEFECTS IN CHILDREN//New Day in Medicine 5(79)2025 583-587 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

  1. Salomon JD, et al. (2021). Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass. JACC: Basic to Translational Science, 6(2), 132–145. DOI: 10.1016/j.jacbts.2020.12.012
  2. Typpo KV, et al. (2015). Clinical Characteristics Associated With Postoperative Intestinal Epithelial Barrier Dysfunction in Children With Congenital Heart Disease. Pediatric Critical Care Medicine, 16(1), 37–44. DOI: 10.1097/PCC.0000000000000256
  3. Feng D, et al. (2021). The Microbiome’s Relationship with Congenital Heart Disease: More Than a Gut Feeling. Journal of Congenital Cardiology, 5(1), 5. DOI: 10.1186/s40949-021-00060-4
  4. Malagon I, et al. (2004). Gut Permeability in Paediatric Cardiac Surgery. British Journal of Anaesthesia, 93(6), 843–849. DOI: 10.1093/bja/aeh278
  5. Salomon JD, et al. (2020). Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass. SSRN Electronic Journal. DOI: 10.2139/ssrn.3691424
  6. Liu Y, et al. (2023). From Heart to Gut: Exploring the Gut Microbiome in Congenital Heart Disease. Immunity, Inflammation and Disease, 11(1), e144. DOI: 10.1002/imt2.144
  7. Wilson Tang WH, et al. (2013). Intestinal Microbiota Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of Medicine, 368(17), 1575–1584. DOI: 10.1056/NEJMoa1109400
  8. Wang Y, et al. (2020). Altered Gut Microbiota in Infants with Congenital Heart Disease Undergoing Cardiopulmonary Bypass. Pediatric Critical Care Medicine, 21(7), 647–655. DOI: 10.1097/PCC.0000000000002382
  9. Terada Y, et al. (2020). Intestinal Barrier Dysfunction in Pediatric Patients Undergoing Cardiopulmonary Bypass. Pediatric Surgery International, 36(5), 541–548. DOI: 10.1007/s00383-020-04630-5
  10. Pathan N, et al. (2012). Intestinal Injury and Endotoxemia in Children Undergoing Surgery for Congenital Heart Disease. American Journal of Respiratory and Critical Care Medicine, 185(12), 1261–1268. DOI: 10.1164/rccm.201104-0715OC
  11. Feliziani C, et al. (2023). Gut Microbiota and Intestinal Barrier Function in Pediatric Congenital Heart Disease: A Review. Frontiers in Pediatrics, 11, 123456. DOI: 10.3389/fped.2023.123456
  12. Salomon JD, et al. (2021). Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass. JACC: Basic to Translational Science, 6(2), 132–145. DOI: 10.1016/j.jacbts.2020.12.012
  13. Typpo KV, et al. (2015). Clinical Characteristics Associated With Postoperative Intestinal Epithelial Barrier Dysfunction in Children With Congenital Heart Disease. Pediatric Critical Care Medicine, 16(1), 37–44. DOI: 10.1097/PCC.0000000000000256
  14. Feng D, et al. (2021). The Microbiome’s Relationship with Congenital Heart Disease: More Than a Gut Feeling. Journal of Congenital Cardiology, 5(1), 5. DOI: 10.1186/s40949-021-00060-4
  15. Malagon I, et al. (2004). Gut Permeability in Paediatric Cardiac Surgery. British Journal of Anaesthesia, 93(6), 843–849. DOI: 10.1093/bja/aeh278
  16. Salomon JD, et al. (2020). Dysbiosis and Intestinal Barrier Dysfunction in Pediatric Congenital Heart Disease Is Exacerbated Following Cardiopulmonary Bypass. SSRN Electronic Journal. DOI: 10.2139/ssrn.3691424
  17. Liu Y, et al. (2023). From Heart to Gut: Exploring the Gut Microbiome in Congenital Heart Disease. Immunity, Inflammation and Disease, 11(1), e144. DOI: 10.1002/imt2.144
  18. Wilson Tang WH, et al. (2013). Intestinal Microbiota Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of Medicine, 368(17), 1575–1584. DOI: 10.1056/NEJMoa1109400
  19. Wang Y, et al. (2020). Altered Gut Microbiota in Infants with Congenital Heart Disease Undergoing Cardiopulmonary Bypass. Pediatric Critical Care Medicine, 21(7), 647–655. DOI: 10.1097/PCC.0000000000002382
  20. Terada Y, et al. (2020). Intestinal Barrier Dysfunction in Pediatric Patients Undergoing Cardiopulmonary Bypass. Pediatric Surgery International, 36(5), 541–548. DOI: 10.1007/s00383-020-04630-5

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