139 -5 (79) 2025 - Khasanov B.B. - INFLUENCE OF EXPERIMENTAL STRESS ON IMMUNITY DURING LACTATION

INFLUENCE OF EXPERIMENTAL STRESS ON IMMUNITY DURING LACTATION

Khasanov B.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Lactation and stressors affect the activity of the immune system, but changes in immune defense as a result of the interaction of both factors have not yet been studied. The article considers data on the effect of social stress on cellular immunity indices in the blood and mesenteric lymph nodes (MLN) of linear white laboratory Wistar rats. It was found that stress and lactation have a significant effect on the immune system. Acute social stress caused granulocytosis, decreased lymphocyte proliferation and cytokine production in the blood, but did not have a significant effect on MLR. In the blood of lactating rats, an increase in the number of granulocytes and increased phagocytosis, but a decrease in the number of B cells and a decrease in IL-2 production were observed. At the same time, in the MLR of lactating rats, both lymphocyte proliferation and an increase in the number of monocytes were observed. The effects of stress on immunity were frequently observed in lactating and non-lactating rats, with some important differences: only lactating animals showed an increase in circulating granulocytes and a decrease in IL-2 production in response to the stressor. Thus, lactation is a unique neuroendocrine state that counteracts stress-induced modulations of at least some immune parameters. Acute social stress (2 h) induced social detrimental effects in lactating and non-lactating female rats using a confrontation model, resulting in increased plasma corticosterone concentrations.

Key words: Lactation and stressor, experimental stress, immunity.

First page

687

Last page

695

For citation:Khasanov B.B. - INFLUENCE OF EXPERIMENTAL STRESS ON IMMUNITY DURING LACTATION//New Day in Medicine 5(79)2025 687-695 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

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