23 -1 (39) 2022 — Daminova X.M. — MODERN VIEW TO OPTIMIZATION OF THE DIAGNOSIS OF THE COURSE OF PARKINSON’S DISEASE

MODERN VIEW TO OPTIMIZATION OF THE DIAGNOSIS OF THE COURSE OF PARKINSON’S DISEASE

Daminova X.M. Tashkent Medical Academy, Tashkent  Uzbekistan,

Resume

Parkinsonism is one of the most significant problems in clinical neurology, both due to its high prevalence in the world’s populations and due to the significant disability of patients. The paper analyzes the diagnosis of Parkinson’s disease (as well as other neurodegenerative diseases) at the prodromal stage. An overview of the methods of preclinical and early clinical diagnosis of BP shows that the study of the prmodromic markers and the criteria of the Premotor Phase Phase of the BP will allow in the future to significantly change the course of the disease using neuroprotective therapy at the stage preceding the death of a significant number of dopaminergic neurons of the Black Substance.

Key words: Parkinson’s disease, patient disability, neuroprotective therapy, long-term markers, black substance.

First page

115

Last page

118

For citation: Daminova X.M. MODERN VIEW TO OPTIMIZATION OF THE DIAGNOSIS OF THE COURSE OF PARKINSON’S DISEASE //New Day in Medicine 1(39)2022 115-118 https://cutt.ly/KOerez1

LIST OF REFERENCES:

1. Zakharov V.V. Neuropsychic disorders: diagnostic tests / V.V. Zakharov, T.G. Voznesenskaya – M.: MED press-inform, – 2013 – p.315.
2. Levin O.S. Diagnosis and treatment of dementia in clinical practice / O.S. Levin – M.: MEDpress-inform, – 2017. – p.254.
3. Litvinenko I.V. Neuroimaging in the diagnosis of nosological forms of parkinsonism and the possibility of predicting the course of Parkinson’s disease /I.V. Litvinenko, M.M. Odinak, A.G. Trufanov, V.A. Fokin, I.V. Boykov // Parkinson’s disease and movement disorders. ed. S.N. Illarioshkina, O.S. Levina. – NTSN RAMS – 2012. – P.113-130. 178
4. Braak H. Staging of brain pathology related to sporadic Parkinson’s disease /Braak H., Del Tredici K., Rüb U., de Vos RAI, Jansen Steur ENH, Braak // Neurobiol Aging.–2003–Vol.24–p .197–210.
5. Nombela C. Genetic impact on cognition and brain function in newly diagnosed Parkinson’s disease: ICICLE-PD study / Nombela C., Rowe J.B., Winder-Rhodes S.E., Hampshire A., Owen A.M., Breen D.P., et al. //brain. – 2014. – Vol. 137. – 2743-58.
6. Otero J.L. Dementia with Parkinson’s disease Clinical diagnosis, neuropsychological aspects and treatment Dementia /Otero J.L. // Neuropsychologia –2018 – December –2(4) – p.261-266
7. Reid W.G. J. Dementia in Parkinson’s disease: a 20-year neuropsychological study (Sydney Multicentre Study) / Reid W.G.J., Hely M. A., Morris J. G. L., Loy C., Halliday G. //J Neurol Neurosurg Psychiatry. – 2011. – Vol.82. – p. 1033.
8. Xu Y. Meta-analysis of risk factors for Parkinson’s disease dementia.A 10-year study of the incidence of and factors predicting dementia in Parkinson’s disease / Xu Y., Yang J., Shang H. // Translational Neurodegeneration [Transl Neurodegener] – 2016 – Jun 01 – Vol. 5-p. eleven.