188 -5 (79) 2025 - Ruziyev Z.M. - ACTIVATION OF THE CD147 SIGNALING PATHWAY BY PLATELETS PROMOTES THE PROINFLAMMATORY PHENOTYPE OF MONOCYTES IN RHEUMATOID ARTHRITIS

ACTIVATION OF THE CD147 SIGNALING PATHWAY BY PLATELETS PROMOTES THE PROINFLAMMATORY PHENOTYPE OF MONOCYTES IN RHEUMATOID ARTHRITIS

Ruziyev Z.M. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and damage. Recent studies have highlighted the crucial role of platelets in the pathogenesis of RA through their interaction with immune cells and contribution to inflammatory processes. In this study, we investigated the role of the surface protein CD147 on platelets in inducing a proinflammatory monocyte phenotype in RA. We found that platelet–monocyte interactions mediated by CD147 lead to phenotypic changes in monocytes, particularly within the CD14++CD16+CCR2+ (Mon2) subset, which is associated with increased production of proinflammatory cytokines and activation of transcription factors such as NF-κB. These findings underscore the important role of platelets in shaping the inflammatory response in RA and propose CD147 as a potential therapeutic target for novel treatment strategies

Keywords: Rheumatoid arthritis, platelets, monocytes, CD147, proinflammatory phenotype, inflammation, cytokines

First page

925

Last page

931

For citation:Ruziyev Z.M. - ACTIVATION OF THE CD147 SIGNALING PATHWAY BY PLATELETS PROMOTES THE PROINFLAMMATORY PHENOTYPE OF MONOCYTES IN RHEUMATOID ARTHRITIS//New Day in Medicine 5(79)2025 925-931 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Aletaha D, Neogi T, Silman A. J., Funovits J, Felson D.T., Bingham C.O. 3rd, Birnbaum N.S., Burmester G.R., Bykerk V.P., Cohen M.D., Combe B., Costenbader K.H., Dougados M, Emery P, Ferraccioli G, Hazes J.M., Hobbs K, Huizinga T.W., Kavanaugh A, Kay J, Kvien T.K., Laing T, Mease P, Ménard H.A., Moreland L.W., Naden R.L., Pincus T, Smolen J.S., Stanislawska-Biernat E, Symmons D, et al: 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010, 62:2569–2581
2. Rossol M, Kaltenhäuser S, Scholz R, Häntzschel H, Hauschildt S, and Wagner U: The contact-mediated response of peripheral blood monocytes to preactivated T cells is suppressed by serum factors in rheumatoid arthritis. Arthritis Res Ther 2005, 7:1189–1199.
3. Rossol M, Meusch U, Pierer M, Kaltenhäuser S, Häntzschel H, Hauschildt S, Wagner U: Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells. J Immunol 2007, 15:4239–4248
4. Galt SW, Lindemann S, Medd D, Allen LL, Kraiss LW, Harris ES, Prescott SM, McIntyre TM, Weyrich AS, Zimmerman GA: Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets. Circ Res 2001, 89:509–516
5. Rossol M, Kraus S, Pierer M, Baerwald C, Wagner U: The CD14bright CD16+monocyte subset is expanded in rheumatoid arthritis and promotes Th17 expansion. Arthritis Rheum 2012, 64:671–677
6. Tapp LD, Shantsila E, Wrigley BJ, Pamukcu B, Lip GY: The CD14++CD16+monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction. J Thromb Haemost 2012, 10:1231–1241
7. Mickelson JK, Lakkis NM, Villarreal-Levy G, Hughes BJ, Smith CW: Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease? J Am Coll Cardiol 1996, 28:345–353
8. Ammon C, Kreutz M, Rehli M, Krause SW, Andreesen R: Platelets induce monocyte differentiation in serum-free coculture. J Leukoc Biol 1998, 63:469–476.
9. Zhou J, Zhu P, Jiang JL, Zhang Q, Wu ZB, Yao XY, Tang H, Lu N, Yang Y, Chen ZN: Involvement of CD147 in over expression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1. BMC Cell Biol 2005, 6:25.
10. Shore A, Jaglal S, Keystone EC: Enhanced interleukin 1 generation by monocytes in vitro is temporally linked to an early event in the onset or exacerbation of rheumatoid arthritis. Clin Exp Immunol 1986, 65:293–302.

    file

    download