191 -5 (79) 2025 - Salimova N.R., Usmanova N.A. - INFLUENCE OF BLACK GARLIC ON THE DYNAMICS OF LIPID PROFILE INDICATORS IN PATIENTS WITH CARDIOVASCULAR DISEASES

INFLUENCE OF BLACK GARLIC ON THE DYNAMICS OF LIPID PROFILE INDICATORS IN PATIENTS WITH CARDIOVASCULAR DISEASES

Salimova N.R. - Republican Specialized Scientific and Practical Medical Center of Cardiology Uzbekistan

Usmanova N.A. - Republican Specialized Scientific and Practical Medical Center of Cardiology Uzbekistan

Makhkamova N.U. - Republican Specialized Scientific and Practical Medical Center of Cardiology Uzbekistan

Alimova D.A. - Republican Specialized Scientific and Practical Medical Center of Cardiology Uzbekistan

Gulomjonov A.G. - Republican Specialized Scientific and Practical Medical Center of Cardiology Uzbekistan

Resume

The aim of the open, observational study was to examine the effect of black garlic in mono- and adjuvant therapy to statins on the dynamics of lipid profile parameters in patients with cardiovascular diseases. 98 patients (35 women and 63 men) with various CVD and dyslipidemia were examined. Patients were divided into 3 groups taking into account the severity of dyslipidemia. The lipid profile was assessed using four parameters determined in a blood biochemistry test: total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. In group 1 (n=43), the effect of black garlic monotherapy (750 mg per day) on the lipid profile was assessed; in group 2 (n=27), patients followed a low-fat diet without pharmacotherapy; in group 3 (n=28), the dynamics of the lipid profile was studied with the combined use of black garlic (750 mg per day) and a statin (rosuva- or atorva-) in average therapeutic doses of 5-10 mg and 10-20 mg, respectively. The duration of treatment and observation was 8 weeks. Recommendations: Black Garlic at a dose of 750 mg per day in monotherapy significantly reduces the levels of TC, LDL-C and TG, is well tolerated and can be recommended for patients with CVD who are intolerant to statins. At the same time, the authors believe that further, larger-scale studies of black garlic are needed as an effective alternative, affordable and safe hypolipidemic agent from the arsenal of ancient and modern folk medicine from the standpoint of evidence-based medicine.

Key words: the effect of black garlic on the dynamics of lipid profile indicators, patients with cardiovascular diseases

First page

940

Last page

945

For citation:Salimova N.R., Usmanova N.A., Makhkamova N.U., Alimova D.A., Gulomjonov A.G. - INFLUENCE OF BLACK GARLIC ON THE DYNAMICS OF LIPID PROFILE INDICATORS IN PATIENTS WITH CARDIOVASCULAR DISEASES//New Day in Medicine 5(79)2025 940-945 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by Region, 2000-2019. Geneva: World Health Organization; 2020.
2. Mach F, et al. Eur Heart J. 2020;41(1):1-77.
3. Banach M, et al. J Am Coll Cardiol. 2022;79(11):1096-1109.
4. Kim MK, et al. J Med Food. 2013;16(11):1000-6.
5. Jung EM, et al. Nutr Res Pract. 2014;8(6):662-7.
6. Ryu JH, et al. J Nutr Health Aging. 2017;21(3):268-278.
7. Li Y, et al. Lipids Health Dis. 2015;14:149.
8. Wang X, et al. J Agric Food Chem. 2010;58(12):7080-7.
9. Rizvi AA, et al. Am J Ther. 2019;26(6):e761-e769.
10. Qin Y, et al. Front Pharmacol. 2021;12:743226.
11. Rivlin RS. Historical perspective on the use of garlic. J Nutr. 2001;131(3s):951S-954S
12. Iciek J, Kwiecień I, Włodek L. Biological properties of garlic and its potential application in the prevention and treatment of diseases. Postepy Hig Med Dosw (Online). 2009;63:751-62
13. Jung EM, Lee SH, Lee DS, et al. Aged garlic extract improves plasma lipid profiles in hypercholesterolemic subjects. Nutr Res. 2014;34(6):516-22.

    file

    download