214 -5 (79) 2025 - Karimova N.N., Nematova M.R. - CHANGES IN ENDOTHELIAL DYSFUNCTION INDICATORS - PREDICTORS OF OBSTETRIC BLEEDING

CHANGES IN ENDOTHELIAL DYSFUNCTION INDICATORS - PREDICTORS OF OBSTETRIC BLEEDING

Karimova N.N. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Nematova M.R. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The main indicators of endothelial dysfunction are endothelin-1 (ET-1), nitric oxide (NO), E-selectin and vascular endothelial growth factor (VEGF). The clinical course of the current pregnancy was studied in 32 of 53 examined pregnant women with a history of massive bleeding, it was uncomplicated, and in 38 pregnant women a threat of miscarriage was detected. In this regard, we decided to divide them into 2 groups: without a threat of miscarriage, with a threat of miscarriage. Individual analysis of endothelial dysfunction indicators showed a pronounced dysfunctional state in pregnant women in the group with a risk of miscarriage. It was revealed that in the 18-24 weeks of pregnancy, the serum levels of ET-1, NO, E-selectin and VEGF in pregnant women without signs of miscarriage increased by 1.66; 1.2; 1.32 and 1.17 times compared to the values of women with a physiological course of pregnancy. In pregnant women with a threat of miscarriage, this excess was 3.33; 1.59; 1.72 and 1.68 times, respectively. It should be noted that in this group of pregnant women, the levels of ET-1, NO, E-selectin and VEGF were 2; 1.32; 1.31 and 1.44 times the values of pregnant women without a threat of miscarriage

Key words: massive obstetric hemorrhage, surgeries, endothelial dysfunction, endothelin-1, nitric oxide, selectin, growth factor, preeclampsia, miscarriage

First page

1053

Last page

1058

For citation:Karimova N.N., Nematova M.R. - CHANGES IN ENDOTHELIAL DYSFUNCTION INDICATORS - PREDICTORS OF OBSTETRIC BLEEDING//New Day in Medicine 5(79)2025 1053-1058 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

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