238 -5 (79) 2025 - Khidirova S.H. - "GENETIC PREDISPOSITION TO LACTOSE INTOLERANCE AND ITS IMPACT ON DIET, BONE DENSITY, AND FRACTURES"

"GENETIC PREDISPOSITION TO LACTOSE INTOLERANCE AND ITS IMPACT ON DIET, BONE DENSITY, AND FRACTURES"

Khidirova S.H. - Samarkand State Medical University

Resume

Evidence is presented that genetic predisposition for lactose intolerance in both adults and young children significantly affects calcium intake, bone density, and bone fractures in postmenopausal women. PCR-based genotyping of lactase gene polymorphisms may complement diagnostic procedures to identify individuals at risk for lactose malabsorption and osteoporosis

Key words: polymorphisms, lactose intolerance, LCT, PCR diagnostics, bone density, and bone fractures in postmenopausal women

First page

1178

Last page

1182

For citation:Khidirova S.H. - "GENETIC PREDISPOSITION TO LACTOSE INTOLERANCE AND ITS IMPACT ON DIET, BONE DENSITY, AND FRACTURES"//New Day in Medicine 5(79)2025 1178-1182 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Bernardes-Silva C.F., Pereira A.C., Alves da Mota G.A., Krieger J.E., Laudanna A.A. Lactase persistence/non-persistence variants, C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS patients // Clinica Chimica Acta. – 2007. - V. 386. - P. 7-11.
2. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I 2002 Identification of a variant associated with adult-type hypolactasia. Nat Genet 30: 233–237.
3. Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Jarvela I 2003 Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut 52: 647–652.
4. Sahi T 1994 Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol 202: 7–20.
5. Metz G, Jenkins DJ, Peters TJ, Newman A, Blendis LM 1975 Breath hydrogen as a diagnostic method for hypolactasia. Lancet 1: 1155–1157
6. Newcomer AD, McGill DB, Thomas PJ, Hofman AF 1975 Prospective comparison of indirect methods for detecting lactase deficiency. N Engl J Med 293: 1232–1236.
7. Hammer HF, Fine KD, Santa Ana CA, Porter JL, Schiller LR, Fordtran JS 1990 Carbohydrate malabsorption. Its measurement and its contribution to diarrhea. J Clin Invest 86: 1936–1944.
8. Barbara M Obermayer-Pietsch 1, Christine M Bonelli, Daniela E Walter, Regina J Kuhn, Astrid Fahrleitner-Pammer, Andrea Berghold, Walter Goessler, Vinzenz Stepan, Harald Dobnig, Georg Leb, Wilfried Renner. Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res 2004 Jan;19(1):42-7. doi: 10.1359/JBMR.0301207.
9. Finkenstedt G, Skrabal F, Gasser RW, Braunsteiner H 1986 Lactose absorption, milk consumption, and fasting blood glucose concentrations in women with idiopathic osteoporosis. BMJ 292: 161–162
10. Horowitz M, Wishart J, Mundy L, Nordin BE 1987 Lactose and calcium absorption in postmenopausal osteoporosis. Arch Intern Med 147: 534–536.

    file

    download