266 -5 (79) 2025 - Jurayev B.R. - DIAGNOSTIC SIGNIFICANCE OF HEMOSTASIS PARAMETERS IN VARIOUS STAGES OF CHRONIC VIRAL HEPATITIS
DIAGNOSTIC SIGNIFICANCE OF HEMOSTASIS PARAMETERS IN VARIOUS STAGES OF CHRONIC VIRAL HEPATITIS
Jurayev B.R. - Bukhara State Medical Institute named after Abu Ali ibn Sina
Resume
Chronic viral hepatitis leads to a gradual deterioration of liver function and causes complex disorders of the hemostasis system. The liver is a major component of hemostasis, synthesizing coagulation factors and anticoagulant proteins. This study was aimed at assessing changes in hemostasis parameters at different stages of chronic viral hepatitis and determining their diagnostic significance. 120 patients with chronic viral hepatitis B and C were included in the study. Patients were divided into groups according to the Child-Pugh classification. Hemostasis parameters (PT, APTT, INR, fibrinogen, D-dimer, antithrombin III) and modern tests (thromboelastography) were performed.
Keywords: chronic viral hepatitis, hemostasis, coagulation, liver cirrhosis, diagnostics
First page
1323
Last page
1328
For citation:Jurayev B.R. - DIAGNOSTIC SIGNIFICANCE OF HEMOSTASIS PARAMETERS IN VARIOUS STAGES OF CHRONIC VIRAL HEPATITIS//New Day in Medicine 5(79)2025 1323-1328 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025
List of References
- Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. N Engl J Med. 2011;365(2):147-156.
- Hugenholtz GC, Porte RJ, Lisman T. The platelet and platelet function in chronic liver disease. Hepatology. 2014;60(4):1494-1502.
- Lisman T, Caldwell SH, Burroughs AK, et al. Hemostasis and thrombosis in patients with liver disease: the ups and downs. J Hepatol. 2010;53(2):362-371.
- Northup PG, McMahon MM, Ruhl AP, et al. Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism. Am J Gastroenterol. 2006;101(7):1524-1528.
- Reverter JC, Tàssies D, Martínez-Brotons F, et al. Longitudinal study of platelet function during orthotopic liver transplantation. Hepatology. 1997;25(2):351-356.
- Senzolo M, Cholongitas E, Burra P, et al. beta-Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis. Liver Int. 2009;29(8):1189-1193.
- Oblokulov Abdurashid Rakhimovich Mukhammadieva Musharraf Ibrokhimovna Sanokulova Sitora Avazovna Khadieva Dora Isakovna. (2023). Clinical and laboratory features of spontaneous bacterial peritonitis in patients with viral liver cirrhosis. Journal of Advanced Zoology, 44(S-2), 3744–3750. Retrieved from http://jazindia.com/index.php/jaz/article/view/1716
- Juraev Bobur Rakhmonovich. (2025). КОКЛЮШ НА СОВРЕМЕННОМ ЭТАПЕ . Ta’lim Innovatsiyasi Va Integratsiyasi, 45(3), 93-99. https://scientific-jl.com/tal/article/view/15002
- Облокулов Абдурашид Рахимович, Санокулова Ситора Авазовна, Жўраев Бобур Рахмонович.(2024) Клинико-Иммунологические Особенности Развития Острой Почечной Недостаточности При Циррозе Печени Вирусной Этиологии. International Journal of Integrative and Modern Medicine . IJIMM, Volume 2, Issue 5, 2024 ISSN: 2995-5319 https://medicaljournals.eu/index.php/IJIMM/issue/view/3
- Juraev Bobur Rakhmonovich.(2024) Modern Therapy of Viral Hepatitis. Interna’onal Journal of Alterna’ve and Contemporary Therapy. IJACT, 2024;2(6) ISSN: 2995-5378 http://medicaljournals.eu/index.php/IJACT
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