286 -5 (79) 2025 - Zhumaev N.A., Teshaev O.R. - PERSONALIZED ANTIBIOTIC THERAPY FOR COMPLICATED INTRAABDOMINAL INFECTION: EFFICACY ANALYSIS BASED ON MICROBIOLOGICAL MONITORING DATA

PERSONALIZED ANTIBIOTIC THERAPY FOR COMPLICATED INTRAABDOMINAL INFECTION: EFFICACY ANALYSIS BASED ON MICROBIOLOGICAL MONITORING DATA

Zhumaev N.A. - Department of Surgical Diseases in Family Medicine, Ibn Sina City Multidisciplinary Clinic No. 1 at Tashkent Medical Academy

Teshaev O.R. - Department of Surgical Diseases in Family Medicine, Ibn Sina City Multidisciplinary Clinic No. 1 at Tashkent Medical Academy

Zhuraev Zh.Z. - Department of Surgical Diseases in Family Medicine, Ibn Sina City Multidisciplinary Clinic No. 1 at Tashkent Medical Academy

Resume

The article is devoted to evaluating the effectiveness of a personalized approach to prescribing antibiotic therapy for complicated intraabdominal infection. A prospective observational study was conducted including 128 patients divided into two groups: standard empirical therapy (n=64) and personalized therapy based on local microbiological monitoring (n=64). The personalized approach showed significantly higher clinical effectiveness (76.6% vs. 59.4%, p=0.037) and microbiological effectiveness (82.8% vs. 65.6%, p=0.027), as well as reduced duration of antibiotic therapy, ICU stay and overall hospitalization.

Keywords: intraabdominal infection, personalized antibiotic therapy, microbiological monitoring, antibiotic resistance.

First page

1412

Last page

1416

For citation:Zhumaev N.A., Teshaev O.R., Zhuraev Zh.Z. - PERSONALIZED ANTIBIOTIC THERAPY FOR COMPLICATED INTRAABDOMINAL INFECTION: EFFICACY ANALYSIS BASED ON MICROBIOLOGICAL MONITORING DATA//New Day in Medicine 5(79)2025 1412-1416 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Sartelli M, Chichom-Mefire A, Labricciosa FM, et al. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. // World J Emerg Surg. 2017;12:29.
2. Russo A, Falcone M, Gutiérrez-Gutiérrez B, et al. Predictors of outcome in patients with severe sepsis or septic shock due to extended-spectrum β-lactamase-producing Enterobacteriaceae. Int J Antimicrob Agents. 2018;52(5):577-585.
3. Friedrich AK, Cahan M. Intraabdominal infections in the intensive care unit. J Intensive Care Med. 2014;29(5):247-254.
4. Lob SH, Badal RE, Bouchillon SK, et al. Epidemiology and susceptibility of Gram-negative appendicitis pathogens: SMART 2008-2010. Surg Infect (Larchmt). 2013;14(2):203-208.
5. Guirao X, Arias J, Badía JM, et al. Recommendations in the empiric anti-infective agents of intra-abdominal infection. Rev Esp Quimioter. 2009;22(3):151-172.
6. Montravers P, Dupont H, Leone M, et al. Guidelines for management of intra-abdominal infections. Anaesth Crit Care Pain Med. 2015;34(2):117-130.
7. Mazuski JE, Tessier JM, May AK, et al. The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection. Surg Infect (Larchmt). 2017;18(1):1-76.
8. Evans HL, Raymond DP, Pelletier SJ, et al. Diagnosis of intra-abdominal infection in the critically ill patient. Curr Opin Crit Care. 2001;7(2):117-121.
9. Rattan R, Allen CJ, Sawyer RG, et al. Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy. J Am Coll Surg. 2016;222(4):440-446.
10. Gutiérrez-Gutiérrez B, Salamanca E, de Cueto M, et al. Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study. Lancet Infect Dis. 2017;17(7):726-734.

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