299 -5 (79) 2025 - Allamurodova F.Y. - DIAGNOSTIC AND PROGNOSTIC ASPECTS OF HEMATOLOGICAL CHANGES IN CHRONIC LIVER DISEASES

DIAGNOSTIC AND PROGNOSTIC ASPECTS OF HEMATOLOGICAL CHANGES IN CHRONIC LIVER DISEASES

Allamurodova F.Y. - Bukhara State Medical Institute named after Abu Ali ibn Sina

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Today, among chronic liver diseases that have a significant economic and social impact on society with their severe complications, chronic viral hepatitis B occupies a special place. Due to the high risk of developing liver cirrhosis and liver cancer because of this disease, early detection and effective treatment of this disease have a significant positive effect on improving the quality of life of patients and increasing their survival. Studying the importance of hematological indicators, which are convenient due to their availability in all treatment and prevention institutions, in the early diagnosis of chronic viral hepatitis B, and using them as an early diagnostic criterion for this disease can yield effective results

Keywords: hepatitis B virus, anemia, thrombocytopenia, hepcidin, vitamin B 12, liver cirrhosis

First page

1480

Last page

1482

For citation:Allamurodova F.Y. - DIAGNOSTIC AND PROGNOSTIC ASPECTS OF HEMATOLOGICAL CHANGES IN CHRONIC LIVER DISEASES//New Day in Medicine 5(79)2025 1480-1482 https://newdayworldmedicine.com/en/new_day_medicine/5-79-2025

List of References

1. Yang, J., Yan, B., Yang, L., et al. (2018).Macrocytic anemia is associated with the severity of liver impairment in patients with hepatitis B virus-related decompensated cirrhosis. BMC Gastroenterology, 18, 161. DOI: 10.1186/s12876-018-0893-9
2. Zhao TY, Cong QW, Liu F, Yao LY, Zhu Y. Nonlinear Relationship Between Macrocytic Anemia and Decompensated Hepatitis B Virus Associated Cirrhosis: A Population-Based Cross-Sectional Study. Front Pharmacol. 2021 Sep 20;12:755625. doi: 10.3389/fphar.2021.755625. PMID: 34616304; PMCID: PMC8488205.
3. Liu, C. H., Hu, T. H., Hung, C. H., et al. (2013). Thrombocytopenia in patients with hepatitis B virus-related chronic hepatitis: evaluation of the immature platelet fraction. Hepatology International, 7(3), 714–720. PMID: 24047408
4. Aminu, M., Bako, I. A., Aliyu, M., et al. (2019). Haematological and Immunological Parameters in Patients with Chronic Hepatitis B Infection in Zaria, Nigeria. Annals of African Medicine, 18(3), 121–125. PMID: 31263806
5. Chen, J., Xu, W., Chen, J., et al. (2021). Immune and Hematological Dysfunctions in Chronic Hepatitis B Infection and Related Liver Disease. Frontiers in Pharmacology, 12, 755625. DOI: 10.3389/fphar.2021.755625
6. K. J. Boltayev, F. Yo. Allamurodova (2024). Gepatit B virusi va uning ta’sirida kelib chiquvchi gematologik o‘zgarishlar. Doktor axborotnomasi, 2024 №2 (114) 137-139.
7. Liu Q., Duan S., Yu Y., et al. (2013). Decreased serum hepcidin concentration correlates with brain iron deposition in patients with HBV-related cirrhosis. PubMed Central (PMC3679136) https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3679136/
8. Gao H., Li Y., Wang D., et al. (2016). Correlation of serum hepcidin levels with disease progression in hepatitis B virus-related disease assessed by nanopore film based assay. Pub Med Central (PMC5046114) https://www.ncbi.nlm.nih.gov/pmc/articles /PMC5046114/
9. Zhao L., Zhang H., Wu W., et al. (2018). Iron metabolism disorders in patients with hepatitis B-related liver diseases. World Journal of Gastroenterology https://www.wjgnet.com/2307-8960/full/v6/i13/600.htm
10. Liu ZW, Han QY, Zhang N, Kang W. Sequential changes of serum ferritin levels and their clinical significance in lamivudine-treated patients with chronic viral hepatitis B. World J Gastroenterol. 2004 Apr 1;10(7):972-6. doi: 10.3748/wjg.v10.i7.972. PMID: 15052677; PMCID: PMC4717115.

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