28 -6 (80) 2025 - Togaev A.T., Onarov N.N. - VITILIGO: PATHOGENESIS, CLINICAL FEATURES, AND ADVANCES IN TREATMENT

VITILIGO: PATHOGENESIS, CLINICAL FEATURES, AND ADVANCES IN TREATMENT

Togaev A.T. - Termez branch of the Tashkent Medical Academy

Onarov N.N. - Termez branch of the Tashkent Medical Academy

Normurodov F.X. - Termez branch of the Tashkent Medical Academy

Resume

The relationship between living conditions and vitiligo in patients of the Surkhandarya Regional Dermatovenerology Dispensary in Uzbekistan is investigated in this research. Vitiligo is an acquired depigmenting skin disease that can haunt individuals thoroughly due to despair because it affects melanocytes – the skin cells responsible for the color. Almost all reports suggest that one or several autoimmune reactions play a role in disease development along with oxidative stress and various environmental factors. This study seeks to establish the possible relationship between overcrowding sanitation and access to water within household and the distribution/ severity of vitiligo in a given community. There were 119 participants in the cross-sectional research study, which involved patients diagnosed with vitiligo and those without vitiligo. Clinical skin assessment, semi-structured interviews and questionnaires were used in the study, where students were asked to provide sociodemographic characteristics, environment data, etc. There were significant differences among Vitiligo patients per subject’s and household characteristics; widespread and progressive vitiligo lesions were more common among respondents who lived in crowded households with limited access to clean water and poor means of hygiene. Also, illiteracy and low awareness of their disease and condition led to delayed diagnosis and poor compliance with the recommended medical therapies. We recommend that, besides the genetic and immunological susceptibility to vitiligo, the social environment factors influence the vitiligo’s progression and the patients’ quality of life. Practice of disease management in any country, particularly in ASHP, requires both individual patient care and general supportive measures such as raising the consciousness of the community on issues of hygiene and improving their standards of living. Controlling the broader social factors is an effective way of improving the quality of life in patients suffering from vitiligo, as well as eliminating the prejudice that they face in rural areas of Uzbekistan

Keywords: Vitiligo, Autoimmune skin disorder, Melanocyte destruction, Overcrowding, Environmental factors, Socioeconomic determinants, Uzbekistan dermatology, Water access and hygiene, Psychosocial stress, Health disparities, Public health infrastructure, Quality of life in vitiligo patients

First page

137

Last page

144

For citation:Togaev A.T., Onarov N.N., Normurodov F.X. - VITILIGO: PATHOGENESIS, CLINICAL FEATURES, AND ADVANCES IN TREATMENT//New Day in Medicine 6(80)2025 137-144 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

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