47 - 6 (80) 2025 - Nazarova A.B. - FEATURES OF VITAMIN D METABOLISM IN THE HUMAN BODY

FEATURES OF VITAMIN D METABOLISM IN THE HUMAN BODY

Nazarova A.B. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Vitamin D metabolism in the human body is a vital biological process that encompasses the study of the epidemiology of vitamin D deficiency, its underlying causes, and the mechanisms of its metabolic pathways. The physiological role of vitamin D remains a subject of ongoing scientific investigation and is not yet fully understood. Hypovitaminosis D is more prevalent during the winter months across all age groups in various regions, including Asia, Europe, Latin America, the Middle East, and North America. A deficiency in vitamin D is associated with a range of health conditions such as rickets, osteoporosis, stroke, myocardial infarction, and infertility-related issues. Several studies have indicated that vitamin D deficiency may influence both insulin secretion and insulin resistance. Insulin resistance is a key characteristic of obesity, one of the most widespread endocrine disorders, particularly among women of reproductive age

Keywords: vitamin D, ergocalciferol (vitamin D2), cholecalciferol (vitamin D3). hormones, fertility, rickets

First page

238

Last page

244

For citation:Nazarova A.B. - FEATURES OF VITAMIN D METABOLISM IN THE HUMAN BODY//New Day in Medicine 6(80)2025 238-244 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

  1. Шварц Г.Я. Витамин D, D-гормон и альфакальцидол: медицинские, молекулярно-биологические и фармакологические аспекты // Украинский ревматологический журнал. — 2019. — № 3 (37). — С. 63–69.
  2. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A. et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline // J. Clin. Endocrinol. Metab. — 2011. — Vol. 96, № 7. — P. 1911–1930. doi:10.1210/jc.2019-0385.
  3. Harel Z., Flanagan P., Forcier M., Harel D. Low vitamin D status among obese adolescents: prevalence and response to treatment // J. Adolesc. Health. — 2018. — Vol. 48. — P. 448–452. doi:10.1016/j.jadohealth.2011.01.011.
  4. Hewison M. Vitamin D and the immune system: new perspectives on an old theme // Endocrinol. Metab. Clin. North Am. — 2019. — Vol. 39, № 2. — P. 365–379. doi:10.1016/j.ecl.2010.02.010.
  5. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A. et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline // J. Clin. Endocrinol. Metab. — 2020. — Vol. 96. — P. 1911–1930. doi:10.1210/jc.2011-0385.
  6. Misra M., Motil K.J., Drezner M.K., Hoppin A.G. Vitamin D insufficiency and deficiency in children and adolescents http://www.uptodate.com (дата обращения: 11.04.2018).
  7. Nazarova A.B. The Role of Vitamin D in the Reproductive System of Women // American Journal of Pediatric Medicine and Health Sciences. — 2023. — ISSN: 2993-2149.
  8. Nazarova A.B. Features of Vitamin D Metabolism in Women of Reproductive Age in the Background of Obesity // Central Asian Journal of Medical and Natural Science. — 2023. — P. 64–66.
  9. Adorini L., Penna G. Control of autoimmune diseases by the vitamin D endocrine system // Nat. Clin. Pract. Rheumatol. — 2008. — Vol. 4, № 8. — P. 404–412.
  10. Von Websky K., Hasan A.A., Reichetzeder C., Tsuprykov O., Hocher B. Impact of vitamin D on pregnancy-related disorders and on offspring outcome // J. Steroid Biochem. Mol. Biol. — 2018. — Vol. 180. — P. 51–64. doi:10.1016/j.jsbmb.2017.11.008.

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