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  • 93 -6 (80) 2025 - Ramazanova Z.F., Ibrohimov N.K. - LOW-MOLECULAR-WEIGHT ANTIOXIDANTS IN THE COMPLEX THERAPY OF TRAUMATIC BRAIN INJURY: EFFECTS ON OXIDATIVE STRESS AND NEURON REPAIR

93 -6 (80) 2025 - Ramazanova Z.F., Ibrohimov N.K. - LOW-MOLECULAR-WEIGHT ANTIOXIDANTS IN THE COMPLEX THERAPY OF TRAUMATIC BRAIN INJURY: EFFECTS ON OXIDATIVE STRESS AND NEURON REPAIR

LOW-MOLECULAR-WEIGHT ANTIOXIDANTS IN THE COMPLEX THERAPY OF TRAUMATIC BRAIN INJURY: EFFECTS ON OXIDATIVE STRESS AND NEURON REPAIR

Ramazanova Z.F. - Tashkent Medical Academy

Ramazanova Z.F. - Tashkent Medical Academy

Resume

This article explores the role of a low-molecular-weight antioxidant agent in the comprehensive treatment of traumatic brain injury (TBI), with a focus on its impact on oxidative stress and neuronal recovery. TBI represents a serious medical challenge, and the search for effective treatment methods remains a pressing issue. Main Part: In the context of this study, the importance of oxidative stress is highlighted as one of the key mechanisms that aggravate damage to nervous tissue after TBI. Various types of antioxidants are discussed, such as vitamin E, vitamin C, and other compounds that can reduce the level of free radicals and protect neurons from injury. Data from clinical studies are presented, confirming the effectiveness of using antioxidants in combination with other therapeutic approaches. The potential mechanisms of antioxidant action are discussed, including improvements in neuronal metabolism and stimulation of neuroplasticity. Conclusion: The results of the study confirm that the use of antioxidants in the comprehensive treatment of TBI can significantly improve neuronal recovery and reduce oxidative stress levels, making this approach promising for clinical practice. This work provides new insights and deepens the understanding of the mechanisms of antioxidant action on the nervous system, which may contribute to the development of effective treatment strategies for patients with TBI

Keywords: traumatic brain injury, acute cerebral insufficiency, antioxidants, 3-methyl-1-phenyl-2-pyrazolone, low-molecular-weight antioxidants, oxidative stress, neuroprotection, lipid peroxidation, neuronal recovery, comprehensive therapy

First page

453

Last page

458

For citation:Ramazanova Z.F., Ibrohimov N.K. - LOW-MOLECULAR-WEIGHT ANTIOXIDANTS IN THE COMPLEX THERAPY OF TRAUMATIC BRAIN INJURY: EFFECTS ON OXIDATIVE STRESS AND NEURON REPAIR//New Day in Medicine 6(80)2025 453-458 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

  1. Белов А. А., Сидоров А. А. Оксидативный стресс и его значение при черепно-мозговой травме // Вестник неврологии, психиатрии и нейрохирургии. – 2021. – Т. 27, №3. – С. 45–50.
  2. Скулачёв В. П. Антиоксиданты в терапии нейродегенеративных заболеваний // Биохимия. – 2017. – Т. 82, №4. – С. 489–501.
  3. Чернов В. А., Лебедев М. Ю. Влияние антиоксидантов на восстановление после черепно-мозговой травмы // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2019. – №7. – С. 22–28.
  4. Hall E. D., Wang J. A., Miller D. M. Relationship of oxidative stress to neuroinflammation and secondary injury after traumatic brain injury // Journal of Neuropathology and Experimental Neurology. – 2020. – Vol. 79, No. 6. – P. 444–456.
  5. Епифанцева Н. Н., Борщикова Т. И., Чурляев Юрий Алексеевич, Раткин И. К., Никифорова Н. В., Клочкова-абельянц С. А., Херингсон Л. Г. Состояние оксидантно-антиоксидантного равновесия при тяжелой черепно-мозговой травме // Общая реаниматология. 2010. №1. URL: https://cyberleninka.ru/article/n/sostoyanie-oksidantno-antioksidantnogo-ravnovesiya-pri-tyazheloy-cherepno-mozgovoy-travme (дата обращения: 24.01.2025).
  6. Patel S. P., Sullivan P. G., Lyttle T. S. et al. Antioxidant therapy in traumatic brain injury: state of the art // Neurotherapeutics. – 2019. – Vol. 16, No. 1. – P. 134–145.
  7. Carney N., Totten A. M., O'Reilly C. et al. Guidelines for the management of severe traumatic brain injury, fourth edition // Neurosurgery. – 2017. – Vol. 80, No. 1. – P. 6–15.
  8. Xiong Y., Peterson P. L., Lee C. P. Mitochondrial dysfunction in traumatic brain injury // Neurochemical Research. – 1999. – Vol. 24, No. 4. – P. 539–545.
  9. Dash P. K., Hergenroeder G., Moore A. N., Bazan N. G. Pathophysiology of traumatic brain injury: impact on neurogenesis and plasticity // Brain Research. – 2016. – Vol. 1640. – P. 11–21.
  10. Маркович С. Д., Кузнецова Н. А. Нейропротекция антиоксидантами при ЧМТ: современные подходы // Российский нейрохирургический журнал 2020. – №2. – С. 33–40.

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