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106 -6 (80) 2025 - Dilmuradova K.R., Ikramova Z.H. - EVALUATION OF THE EFFECT OF METHYLXANTHINE THERAPY IN APNEA IN PREMATURE INFANTS

EVALUATION OF THE EFFECT OF METHYLXANTHINE THERAPY IN APNEA IN PREMATURE INFANTS

Dilmuradova K.R. - Samarkand State Medical University

Ikramova Z.H. - Samarkand State Medical University

Ziyadullayeva X.O. - Samarkand State Medical University

Xudoyberdiyeva Sh. - Samarkand State Medical University

To'rayeva I. - Samarkand State Medical University

Ravshanova B. - Samarkand State Medical University

Resume

This article examines the effectiveness of caffeine citrate in premature infants with sleep apnea syndrome. In a study of 120 premature infants, the frequency and duration of episodes of sleep apnea, as well as the effectiveness of therapy, were analyzed. The results showed that treatment with caffeine citrate reduces the frequency of apnea attacks, stabilizes infants' breathing and prevents the development of complications. A comparison with the literature data indicates the high efficacy of caffeine citrate in the prevention and treatment of apnea in premature infants [2]

Keywords: premature newborns, apnea, respiratory distress syndrome, caffeine citrate, treatment efficacy, neonatology

First page

518

Last page

522

For citation:Dilmuradova K.R., Ikramova Z.H., Ziyadullayeva X.O., Xudoyberdiyeva Sh., To'rayeva I., Ravshanova B. - EVALUATION OF THE EFFECT OF METHYLXANTHINE THERAPY IN APNEA IN PREMATURE INFANTS//New Day in Medicine 6(80)2025 518-522 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

  1. Lawn J.E., Cousens S., Zupan J. 4 million neonatal deaths: When? Where? Why? Lancet. 2005;365(9462):891-900 (4 million neonatal deaths: when? Where? Why? - PubMed).
  2. Schmidt B., Roberts R.S., Davis P. et al. Caffeine Therapy for Apnea of Prematurity. N. Engl. J. Med. 2006;354(20):2112–2121 ( The Use of Caffeine Citrate in the Management of Neonatal Apnea in Low‐ and Middle‐Income Countries: A Rapid Systematic Review - PMC ) ( The Use of Caffeine Citrate in the Management of Neonatal Apnea in Low‐ and Middle‐Income Countries: A Rapid Systematic Review - PMC ).
  3. Schmidt B., Roberts R.S., Davis P. et al. Long-Term Effects of Caffeine Therapy for Apnea of Prematurity. N. Engl. J. Med. 2007;357(19):1893–1902 ( The Use of Caffeine Citrate in the Management of Neonatal Apnea in Low‐ and Middle‐Income Countries: A Rapid Systematic Review - PMC ) ( The Use of Caffeine Citrate in the Management of Neonatal Apnea in Low‐ and Middle‐Income Countries: A Rapid Systematic Review - PMC ).
  4. Abdel-Hady H., Nasef N., Shabaan A.E., Nour I. Caffeine therapy in preterm infants. World J. Clin. Pediatr. 2015;4(4):81–93 ( Caffeine therapy in preterm infants - PMC ) ( Caffeine therapy in preterm infants - PMC ).
  5. Ofori E.K., Chirawurah D., Osei-Bonsu E. et al. The Use of Caffeine Citrate in the Management of Neonatal Apnea in Low- and Middle-Income Countries: A Rapid Systematic Review. Health Sci. Rep. 2025;8(2):e1225 ( The Use of Caffeine Citrate in the Management of Neonatal Apnea in Low‐ and Middle‐Income Countries: A Rapid Systematic Review - PMC ) ( The Use of Caffeine Citrate in the Management of Neonatal Apnea in Low‐ and Middle‐Income Countries: A Rapid Systematic Review - PMC )

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