50 -1 (39) 2022 — J.T. Bafaev, A.A. Mavlanov — FEATURES OF THE TYPOLOGICAL PROPERTIES OF ANIMALS IN THE CLINICAL COURSE OF AN EXPERIMENTAL MODEL OF ALLOXAN DIABETES
FEATURES OF THE TYPOLOGICAL PROPERTIES OF ANIMALS IN THE CLINICAL COURSE OF AN EXPERIMENTAL MODEL OF ALLOXAN DIABETES
J.T. Bafaev, Tashkent State Dental Institute, Uzbekistan
A.A. Mavlanov, Tashkent State Dental Institute, Uzbekistan
Z.N. Xamidova Tashkent State Dental Institute, Uzbekistan
Resume
This review discusses the features of the individual-typological approach of the body’s response to the disease, using laboratory animals. Literature data related to the ideas about the pathogenesis of the development of the clinical and morphological picture of the disease, the possibility of extrapolating the results is summarized, and the advantages and disadvantages of each of the models are analyzed. Based on the presented data, it was concluded that it is necessary to approach the pathogenesis, manifestation of clinical forms, complications, treatment, and prevention of the development of the disease from the point of view of individual typological reactions of the organism. The question remains open about the features of the course of diabetes mellitus and its complications by the type of deep and superficial skin wounds with varying degrees of severity. Perhaps the study of such conditions in various typological behaviors may indeed pave the way for the choice of personalized diagnosis and treatment. The solution of these problems involves the use of an integrated approach that allows you to correctly integrate within the framework of a single concept and methods of modern experimental, scientific and practical medicine.
Key words: diabetes mellitus; experimental diabetes; alloxan; typology.
First page
257
Last page
263
For citation: J.T. Bafaev, A.A. Mavlanov, Z.N. Xamidova FEATURES OF THE TYPOLOGICAL PROPERTIES OF ANIMALS IN THE CLINICAL COURSE OF AN EXPERIMENTAL MODEL OF ALLOXAN DIABETES //New Day in Medicine 1(39)2022 257-263 https://cutt.ly/7O79UDh
LIST OF REFERENCES:
- Wright CI, Kroner CI, Draijer R. Non-invasive methods and stimuli for evaluating the skin’s microcirculation. //J Pharmacol Toxicol Methods. 006; 54(1):1–25. doi: 10.1016/j. vascn.2005.09.004.
- Roustit M., Cracowski J.L. Non-invasive assessment of skin microvascular function in humans: an insight into methods. //Microcirculation. 2012;19(1):47–64. doi: 10.1111/j.1549-8719.2011.00129. x.
- Gurfinkel Yu. Computer capillaroscopy as a channel of local visualization, noninvasive diagnostics, and screening of substances in circulating blood. Proc. SPIE; 4241. Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II (May 4, 2001). p. 467. doi: 10.1117/12.431560.
- Allen J. Photoplethysmography and its application in clinical physiological measurement. //Physiol Meas. 2007;28(3):R1–39.
- Крупаткин А.И., Сидоров В.В., ред. Лазерная доплеровская флоуметрия микроциркуляции крови. /М.: Медицина; 2005. 125 с.
- Рогаткин Д.А. Физические основы оптической оксиметрии. /Лекция. Медицинская физика. 2012;(2):97–114.
- Иваницкий Г.P., Хижняк Е.П., Деев А.А. Биофизические основы медицинского тепловидения. Биофизика. 2012;57(1):130–9.
- Балаболкин М.И. Диабетология: монография. – М.: Медицина, 2000. – 672 с.
- Эльбекьян К.С. Особенности нарушения макро- и микроэлементного спектра сыворотки крови при экспериментальном сахарном диабете / К.С. Эльбекьян, А.Б. Ходжаян, А.Б. Муравьёва // Фундаментальные исследования. 2011. №10 (часть 2). С. 411-413.
- Das J. Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis / J. Das, V. Vasan, P.C. Sil // Toxicol. Appl Pharmacol. – 2012. – V. 258. – P. 296-308.
- Effect of streptozotocin on the ultrastructure of rat pancreatic islets / M.D. Mythili [et al.] // Microsc Res Tech. 2004. V. 63. P. 274-281.
- Elsner M. Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulinproducing cells / M. Elsner, E. Gurgul-Convey, S. Lenzen // Free Radic Biol Med. 2006. V. 41. P. 825-834.
- Etuk E.U. Animals models for studying diabetes mellitus / E.U. Etuk // Agric. Biol. J.N. am. 2010. 1 (2). P. 130-134.
- Experimental model of induction of diabetes mellitus in rats / C.S. Macedo [et al.] // Plastic surgery, laboratory of plastic surgery: Sao Paulo – Paulista School of Medicine. 2005. P. 2-5.
- Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan / M. Elsner [et al.] // Diabetologia. 2002. V.45. P. 1542-1549.
- Induction of type 1 diabetes rnellitus in’ laboratory rats by use of attoxan route of administration, pitfalls, and insulin treatment / I.F. Federiuk [et al.] // Comprehensive Medicine. 2004. V. 54. P. 252-257.
- Lenzen S. The mechanisms of alloxan and streptozotocin induced diabetes / S. Lenzen // Diabetologia. 2008. – V. 51. P. 216-226.
- Antia B.S. Hypoglyacaemic effect of aqueous leaf extract of Persea Americana (Mill,) on alloxan induced diabetic rats / B.S. Antia, J.E. Okokon, P.A. Okon // Indian J. pharmacol. 2005. V. 37. P. 325-326.
- Anti-diabetic and antioxidant effects of Zingiber Officinale on alloxan-induced and insulin-resistant diabetic male rats / B.O. Iranloye [et. al] // J. Physiol. Sci. – 2011. – V. 26. – P. 89-96.
- Antihyperglycemic and antihyperlipidemic activity of plectranthus amboinicus on normal and alloxaninduced diabetic rats /A.H. Viswanathaswamy [et. al] // Ind. J. Pharm. Sci. – 2011. – V. 73. – P. 139-45.