129 -6 (80) 2025 - Makhmudova L.I., Turaev R.T. - A NEW METHOD FOR STRATIFYING THE RISK OF COMPLICATIONS OF CIRRHOSIS OF THE LIVER OF VIRAL ETIOLOGY

A NEW METHOD FOR STRATIFYING THE RISK OF COMPLICATIONS OF CIRRHOSIS OF THE LIVER OF VIRAL ETIOLOGY

Makhmudova L.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Turaev R.T. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

An integrative method of stratification of the risk of complications of cirrhosis of the liver of viral etiology has been developed, including a comprehensive assessment of clinical, laboratory, instrumental and biochemical parameters (albumin, bilirubin, INR, fibroelastometry, platelets, and degree of VVP). A cohort study (n=90) with 6‑month follow-up was conducted. The risk index (RPI) was developed and validated, demonstrating AUC=0.88; sensitivity 84%, specificity 80%. As a result, the incidence of complications decreased (ascites -28%, encephalopathy -32%), hospitalizations (-35%), improved clinical and biochemical parameters and quality of life (CLDQ +22%)

Key words: cirrhosis of the liver, viral etiology, risk stratification, fibroelastometry, complications, indicator of cerebral palsy

First page

654

Last page

656

For citation:Makhmudova L.I., Turaev R.T. - A NEW METHOD FOR STRATIFYING THE RISK OF COMPLICATIONS OF CIRRHOSIS OF THE LIVER OF VIRAL ETIOLOGY//New Day in Medicine 6(80)2025 654-656 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

1. World Health Organization. Global Hepatitis Report 2022. Geneva: WHO; 2022.
2. Asriev D.A. и др. Современные подходы к диагностике и лечению цирроза печени. // Гепатология сегодня. – 2021. – №2. – С. 23–28.
3. Министерство здравоохранения Республики Узбекистан. Единый республиканский отчёт по вирусным гепатитам, 2023.
4. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Management of decompensated cirrhosis. // J Hepatol. – 2018. – 69(2). – P. 406–460.
5. Bosch J., Abraldes J.G., Berzigotti A., García-Pagán J.C. The clinical use of HVPG measurements in chronic liver disease. // Nat Rev Gastroenterol Hepatol. – 2009. – 6(10): 573–582.

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