132 -6 (80) 2025 - Sharipov J.N., Makhmudova L.I. - EFFECTIVENESS OF COMBINED THERAPY OF NON-ALCOHOLIC FATTY LIVER DISEASE, TAKING INTO ACCOUNT THE INTESTINAL MICROBIOTA

EFFECTIVENESS OF COMBINED THERAPY OF NON-ALCOHOLIC FATTY LIVER DISEASE, TAKING INTO ACCOUNT THE INTESTINAL MICROBIOTA

Sharipov J.N. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Makhmudova L.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The aim of the study was to study the clinical and laboratory effectiveness of a combined approach in the treatment of non-alcoholic fatty liver disease (NAFLD), taking into account the composition of the intestinal microbiota. The study involved 90 patients with NAFLD, divided into three groups depending on the treatment. The first group received standard therapy, the second group received combination therapy with probiotics, and the third group received an additional personalized selection of probiotics based on microbiological analysis. The results showed the advantage of microbiota-based therapy in reducing transaminase levels, improving ultrasound imaging, and restoring microbiocenosis

Key words: non-alcoholic fatty liver disease, intestinal microbiota, combination therapy, probiotics, dysbiosis

First page

670

Last page

673

For citation:Sharipov J.N., Makhmudova L.I. - EFFECTIVENESS OF COMBINED THERAPY OF NON-ALCOHOLIC FATTY LIVER DISEASE, TAKING INTO ACCOUNT THE INTESTINAL MICROBIOTA//New Day in Medicine 6(80)2025 670-673 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

  1. Баранов А.А., Гребенева Н.Н. Неалкогольная жировая болезнь печени: патогенез, диагностика и лечение. — М., 2022.
  2. Chalasani N. et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guidance. Hepatology. 2021;74(2):708–729.
  3. Tarantino G. et al. NAFLD and microbiota: the gut-liver axis. Int J Mol Sci. 2022;23(2):470.
  4. Tilg H., Moschen A.R. Evolution of inflammation in nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2010;7(3):169–178.
  5. Le Roy T. et al. The intestinal microbiota regulates host cholesterol homeostasis. BMC Biol. 2019;17(1):94.

    file

    download