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  • 51 -1 (39) 2022 — Kamalov T.T., Khaidarov M.O., — DOPPLER ULTRASONIC RESULTS IN PATIENTS WITH NEUROISCHEMIC DIABETIC FOOT SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE

51 -1 (39) 2022 — Kamalov T.T., Khaidarov M.O., — DOPPLER ULTRASONIC RESULTS IN PATIENTS WITH NEUROISCHEMIC DIABETIC FOOT SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE

DOPPLER ULTRASONIC RESULTS IN PATIENTS WITH NEUROISCHEMIC DIABETIC FOOT SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE

Kamalov T.T., Khaidarov M.O., Mirzaev K.K.

Republican Specialized Scientific and Practical Medical Center of Endocrinology of the Ministry of Health of the Republic of Uzbekistan named after acad. Y.H.Turakulova, Andijan State Medical Institute

Resume

We have studied the results of Doppler ultrasound in patients with neuroischemic form of diabetic foot syndrome associated with chronic heart failure in coronary heart disease. The material of the study was 64 patients with DFS, a neuroischemic form of DFS and IHD, who were admitted during 2021 on the basis of the Department of Surgery of the State Medical Institute and the RSNPMTSE of the Ministry of Health of the Republic of Uzbekistan, the estate of acad. Y.H. Turakulova. The patients were divided into 4 groups. In the main 3 groups of patients with type 2 DM, during metabolic stimulation of the MCA endothelium, a negative response was obtained in 38 out of 45 patients (84.4%) of the patient, in 7 (15.5%) patients – a paradoxical MCA response. In the 4th group (comparison group), when assessing cerebrovascular reactivity, a significant dynamics of the peak systolic blood flow velocity of the MCA was obtained up to 14%, the time-averaged maximum blood flow velocity was up to 28% (p<0.05). Only in 6 (40%) patients the SMA reaction was negative. The final conclusion is that the combined effect of hemodynamic and metabolic disorders has the greatest damaging effect on the arterial endothelium. In all patients with type 2 diabetes mellitus in combination with coronary artery disease, dysfunction of the endothelial mechanism of regulation of vascular tone was revealed – in 84%.

Key words: diabetic foot syndrome, Doppler sonography, CHF

First page

264

Last page

269

For citation: Kamalov T.T., Khaidarov M.O., Mirzaev K.K. DOPPLER ULTRASONIC RESULTS IN PATIENTS WITH NEUROISCHEMIC DIABETIC FOOT SYNDROME ASSOCIATED WITH CHRONIC HEART FAILURE //New Day in Medicine 1(39)2022 264-269 https://cutt.ly/PO73qUm

LIST OF REFERENCES:

  1. Jean-Louis Schlienger 1 [Type 2 diabetes complications] Presse Med. 2013 May;42(5):839-48. Doi: 10.1016/j.lpm.2013.02.313. Epub 2013 Mar 23.
  2. Isa Dietrich 1 2, Gustavo Arruda Braga 3, Fernanda Gomes de Melo 3, Ana Carolina Calmon da Costa Silva Silva 3The Diabetic Foot as a Proxy for Cardiovascular Events and Mortality Review Curr Atheroscler Rep. 2017 Oct 2;19(11):44. Doi: 10.1007/s11883-017-0680-z.
  3. Barbara Bohn 1 2, Arthur Grünerbel 3, Marcus Altmeier 4, Carsten Giesche 5, Martin Pfeifer 6, Diabetic foot syndrome in patients with diabetes. A multicenter German/Austrian DPV analysis on 33 870 patients //Diabetes Metab Res Rev. 2018 Sep;34(6):e3020.doi: 10.1002/dmrr.3020. Epub 2018 Jun 1.
  4. Roper N.A,. Bilous R.W,. Kelly W.F,. Unwin N.C, and V.M. Connolly, “Excess mortality in a population with diabetes and the impact of material deprivation: longitudinal, population based study,” British Medical Journal, vol. 322, no. 7299, pp. 1389–1393, 2001.
  5. Kannel W.B. and McGee D.L. “Diabetes and cardiovascular disease: the Framingham study,” The Journal of the American Medical Association, vol. 241, no. 19, pp. 2035–2038, 1979.
  6. J.S. Rana, M. Nieuwdorp, J.W. Jukema, and J.J. P. Kastelein, “Cardiovascular metabolic syndrome—an interplay of, obesity, inflammation, diabetes and coronary heart disease,” Diabetes, Obesity and Metabolism, vol. 9, no. 3, pp. 218–232, 2007.
  7. Pinto A. Tuttolomondo D. di Raimondo et al., “Ischemic stroke in patients with diabetic foot,” International Angiology, vol. 26, no. 3, pp. 266–269, 2007.View at:
  8. Tuttolomondo S. La Placa D. Di Raimondo et al., “Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity,” Cardiovascular Diabetology, vol. 9, article 50, 2010.
  9. Статистика смертности по данным Росстат. Статистика и показатели (2020). Дата обращения: 25 января 2021.
  10. Ranya N. Sweis, Arif Jivan. Обзор ишемической болезни сердца. Справочник MSD (декабрь 2018). Дата обращения: 25 января 2021.
  11. H. Sell and J. Eckel, “Chemotactic cytokines, obesity and type 2 diabetes: in vivo and in vitro evidence for a possible causal correlation?” Proceedings of the Nutrition Society, vol. 68, no. 4, pp. 378–384, 2009.
  12. J.P. Bastard, M. Maachi, C. Lagathu et al., “Recent advances in the relationship between obesity, inflammation, and insulin resistance,” European Cytokine Network, vol. 17, no. 1, pp. 4–12, 2006.

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