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  • 140 -6 (80) 2025 - Hikmatov J.S. - OBSTRUCTIVE SLEEP APNEA AND CARDIOVASCULAR DISEASE: MECHANISMS, CLINICAL IMPLICATIONS, AND MANAGEMENT INSIGHTS

140 -6 (80) 2025 - Hikmatov J.S. - OBSTRUCTIVE SLEEP APNEA AND CARDIOVASCULAR DISEASE: MECHANISMS, CLINICAL IMPLICATIONS, AND MANAGEMENT INSIGHTS

OBSTRUCTIVE SLEEP APNEA AND CARDIOVASCULAR DISEASE: MECHANISMS, CLINICAL IMPLICATIONS, AND MANAGEMENT INSIGHTS

Hikmatov J.S. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This literature review explores the association between obstructive sleep apnea (OSA) and cardiovascular disease (CVD), highlighting mechanisms such as chronic intermittent hypoxia, oxidative stress, and endothelial dysfunction. The paper discusses clinical implications of OSA on hypertension, heart failure, arrhythmias, and stroke, and evaluates the impact of treatments such as CPAP and weight loss. Emphasis is placed on emerging strategies for diagnosis and personalized interventions to mitigate CVD risks in OSA patients

Keywords: obstructive sleep apnea, cardiovascular disease, intermittent hypoxia, CPAP, hypertension, endothelial dysfunction

First page

712

Last page

716

For citation:Hikmatov J.S. - OBSTRUCTIVE SLEEP APNEA AND CARDIOVASCULAR DISEASE: MECHANISMS, CLINICAL IMPLICATIONS, AND MANAGEMENT INSIGHTS//New Day in Medicine 6(80)2025 712-716 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

  1. Aslan, A. et al. (2020). CPAP and cardiovascular outcomes: A meta-analysis. Journal of Clinical Sleep Medicine, 16(7), 1111–1120.
  2. McEvoy, R. D. et al. (2016). CPAP for prevention of cardiovascular events in obstructive sleep apnea. NEJM, 375(10), 919–931.
  3. Iftikhar, I. H. et al. (2013). Effects of CPAP on cardiovascular outcomes. Chest, 143(4), 1070–1077.
  4. Chen, X. et al. (2019). Impact of CPAP on carotid intima-media thickness in OSA: A meta-analysis. Sleep Medicine, 56, 163–170.
  5. Barceló, A. et al. (2019). Inflammatory markers in OSA and response to CPAP. Respiratory Research, 20, 84.
  6. Svatikova, A. et al. (2015). Irisin and metabolic parameters after CPAP. Journal of Sleep Research, 24(5), 515–521.
  7. Bratton, D. J. et al. (2014). CPAP therapy and blood pressure: A meta-analysis. JAMA, 312(20), 2073–2083.
  8. Pépin, J. L. et al. (2010). Adherence to CPAP and blood pressure outcomes. American Journal of Respiratory and Critical Care Medicine, 182(7), 958–965.
  9. Gaddam, K. et al. (2010). Spironolactone in resistant hypertension with OSA. Hypertension, 57(3), 532–539.
  10. Harsch, I. A. et al. (2018). CPAP and glycemic control in diabetes: A meta-analysis. Diabetes Care, 41(2), e22–e24.

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