147 -6 (80) 2025 - Vokhidov J.J. - PSORIATIC ARTHRITIS IN PATIENTS WITH SEVERE PSORIASIS: CLINICAL AND LABORATORY PARALLELS

PSORIATIC ARTHRITIS IN PATIENTS WITH SEVERE PSORIASIS: CLINICAL AND LABORATORY PARALLELS

Vokhidov J.J. - Samarkand State Medical University

Resume

Psoriatic arthritis (PsA) often accompanies severe forms of psoriasis and is characterized by systemic inflammation, involvement of joints, skin, and possible involvement of internal organs. Purpose of the study: to determine clinical and laboratory features of psoriatic arthritis in patients with severe forms of psoriasis and to establish the relationship between the activity of skin and joint syndromes. Materials and methods: clinical and laboratory examination of 84 patients with severe forms of psoriasis (PASI ≥ 15) was carried out. Psoriatic arthritis was diagnosed in 48 of them according to CASPAR criteria. All patients were evaluated for PASI, joint status, levels of C-reactive protein (CRP), COE and other inflammatory markers. Spearman correlation analysis was used to evaluate relationships. RESULTS: Patients with PsA had higher values of PASI, CRP and SOE compared to patients without joint lesions. There was a significant positive correlation between the severity of skin manifestations and laboratory signs of systemic inflammation, as well as the number of inflamed joints. Conclusion: severe course of psoriasis is associated with high frequency of psoriatic arthritis and systemic inflammation. The established clinical and laboratory parallels confirm the need for early rheumatologic screening and a comprehensive approach to the treatment of patients with severe psoriasis.

Keywords: psoriatic arthritis, psoriasis, PASI, CRP, joint syndrome, inflammation.

First page

747

Last page

751

For citation:Vokhidov J.J. - PSORIATIC ARTHRITIS IN PATIENTS WITH SEVERE PSORIASIS: CLINICAL AND LABORATORY PARALLELS//New Day in Medicine 6(80)2025 747-751 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

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