• Home
  • NEW DAY MEDICINE
  • 6 (80) 2025
  • 165 -6 (80) 2025 - Rakhimova M.M., Aripov Sh.M. - RENAL DAMAGE IN CARDIOVASCULAR DISEASES: PATHOGENETIC RELATIONSHIPS AND CLINICAL FEATURES

165 -6 (80) 2025 - Rakhimova M.M., Aripov Sh.M. - RENAL DAMAGE IN CARDIOVASCULAR DISEASES: PATHOGENETIC RELATIONSHIPS AND CLINICAL FEATURES

RENAL DAMAGE IN CARDIOVASCULAR DISEASES: PATHOGENETIC RELATIONSHIPS AND CLINICAL FEATURES

Rakhimova M.M. - Samarkand City Medical Association

Aripov Sh.M. - Samarkand State Medical University

Resume

Kidney damage in cardiovascular diseases (CVD) is one of the key problems of modern clinical medicine, reflecting the close pathophysiologic relationship between heart and kidney function. Disturbance of one of these systems inevitably leads to decompensation of the other, which is the basis of cardio-renal syndrome. In this paper the mechanisms of kidney damage in such diseases as chronic heart failure, arterial hypertension and ischemic heart disease are considered. The analysis of clinical and laboratory parameters demonstrating the frequency and nature of renal dysfunction in patients with CHF is presented. Pathogenetic interrelationships between the decrease in the glomerular filtration rate, inflammatory markers and the severity of cardiac pathology are revealed. The importance of early diagnosis and a comprehensive approach to the treatment of such patients to improve prognosis and reduce cardiac renal risk is emphasized.

Keywords: chronic kidney disease, cardio-renal syndrome, heart failure, ischemic heart disease, arterial hypertension, glomerular filtration rate.

First page

853

Last page

857

For citation:Rakhimova M.M., Aripov Sh.M. - RENAL DAMAGE IN CARDIOVASCULAR DISEASES: PATHOGENETIC RELATIONSHIPS AND CLINICAL FEATURES//New Day in Medicine 6(80)2025 853-857 https://newdayworldmedicine.com/en/new_day_medicine/6-80-2025

List of References

  1. Всемирная организация здравоохранения. Cardiovascular diseases (CVDs). WHO, 2023. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases
  2. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990–2020: a systematic analysis. // Lancet. 2022; 398(10302):1329–1349.
  3. Ronco C., Haapio M., House A.A., Anavekar N., Bellomo R. Cardiorenal syndrome. // J Am Coll Cardiol. 2008;52(19):1527–1539.
  4. Damman K., Valente M.A., Voors A.A., O'Connor C.M., van Veldhuisen D.J., Hillege H.L. Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis. // Eur Heart J. 2014;35(7):455–469.
  5. Ponikowski P., Voors A.A., Anker S.D. et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. // Eur Heart J. 2016;37(27):2129–2200.
  6. Kazory A., Ronco C. Cardiorenal syndrome: recent advances. // Semin Nephrol. 2021;41(1):95–104.
  7. KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease. // Kidney Int. 2021;99(3S):S1–S87.
  8. Глушко О.В., Захарова Н.Е., Ракитина Т.В. Кардио-ренальный синдром: современные представления о патогенезе и подходах к терапии. // Терапевтический архив. 2021;93(3):50–56.
  9. Макарова А.А., Соловьёв А.И. Взаимосвязь сердечно-сосудистой и почечной патологии: взгляд клинициста. // Кардиология. 2020;60(12):69–75.
  10. Sarraf M., Masoumi A., Schrier R.W. Cardiorenal syndrome in acute decompensated heart failure. // Clin J Am Soc Nephrol. 2009;4(12):2013–2026.
  11. House A.A., Anand I., Bellomo R., Cruz D., et al. Definition and classification of cardiorenal syndromes: workgroup statements from the 7th ADQI consensus conference. // Nephrol Dial Transplant. 2010;25(5):1416–1420.
  12. Matsushita K., Coresh J., Sang Y., et al. Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data. // Lancet Diabetes Endocrinol. 2015;3(7):514–525.

    file

    download