23 -7 (81) 2025 - Makhmudova Z.T., Kholboeva G.B. - IMMUNOHISTOCHEMICAL FEATURES OF THE LIVER IN EXPERIMENTAL ACUTE CEREBRAL CIRCULATION DISORDERS

IMMUNOHISTOCHEMICAL FEATURES OF THE LIVER IN EXPERIMENTAL ACUTE CEREBRAL CIRCULATION DISORDERS

Makhmudova Z.T. - Tashkent State Medical University

Kholboeva G.B. - Tashkent State Medical University

Resume

The Ki 67 marker, which is expressed in the perinuclear region of any cell in determining the proliferative index in hepatocytes, is a marker that determines proliferative activity. This plays an important role in assessing the proliferative index of hepatocytes and fibroblasts. This plays an important role in evaluating the proliferative index of hepatocytes and fibroblasts. R53 protein is a pro-apoptotic factor, and due to the accumulation of anomalous proteins, oncoproteins, and various foreign mutant proteins in the cytoplasm of cells, induced cell apoptosis occurs by activating the apoptosis mechanism in the cell. This means that the apoptosis process continued with increased expression of the P53 marker, which is often associated with a higher probability of tumor progression. In order to avoid confusion in our studies, a comparison with the Ki-67 marker was carried out along with the test panel, since P53 often indicates a higher probability of tumor progression

Key words: cerebrovascular disease, liver, immunohistochemistry, morphology

First page

114

Last page

120

For citation:Makhmudova Z.T., Kholboeva G.B. - IMMUNOHISTOCHEMICAL FEATURES OF THE LIVER IN EXPERIMENTAL ACUTE CEREBRAL CIRCULATION DISORDERS//New Day in Medicine 7(81)2025 114-120 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

List of References

1. Bleibel W. et al. Peripheral platelet count correlates with liver atrophy and predicts long‐term mortality on the liver transplant waiting list //Transplant International. – 2013. – Т. 26. – №. 4. – С. 435-442.
2. Braet F., Wisse E. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review //Comparative hepatology. – 2002. – Т. 1. – №. 1. – С. 1-17
3. Calmet F., Martin P., Pearlman M. Nutrition in patients with cirrhosis //Gastroenterology & hepatology. – 2019. – Т. 15. – №. 5. – С. 248.
4. Carvalho J. R., Machado M. V. New insights about albumin and liver disease //Annals of hepatology. – 2018. – Т. 17. – №. 4. – С. 547-560.
5. Chen X., Zhang D., Cao H., Li Y., Lu Y. Hepatic injury following cerebral ischemia promotes hepcidin expression via HMGB1 pathway // Journal of Neuroinflammation. – 2022. – Vol. 19. – Article 63. – DOI: 10.1186/s12974-022-02405-9.
6. Cheshik I. A., Sharshakova T. M., Shcherbakova E. N. Medical and Social Assessment of Mens Reproductive Health //Health and Ecology Issues. – 2019. – №. 1. – С. 77-85.
7. Cheung K., Lee S. S., Raman M. Prevalence and mechanisms of malnutrition in patients with advanced liver disease, and nutrition management strategies //Clinical Gastroenterology and Hepatology. – 2012. – Т. 10. – №. 2. – С. 117-125.
8. Child C. G. Surgery and portal hypertension //The liver and@ ortal hypertension. – 1964. – С. 1-85.
9. Dasarathy S., Merli M. Sarcopenia from mechanism to diagnosis and treatment in liver disease //Journal of hepatology. –2016.Т. 65.№. 6. – С. 1232-1244.
10. de Mattos A. A. Current indications for the use of albumin in the treatment of cirrhosis //Annals of hepatology. – 2016. – Т. 10. – №. S1. – С. 15-20.

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