31 -7 (81) 2025 - Malikova N.N., Arifov S.S. - FEATURES OF POLYMORPHISM OF THE GENE OF THE INTERLEUKIN FAMILY C174G (RS1800795) IL6 IN THE DEVELOPMENT OF ACNE INFLAMMATION

FEATURES OF POLYMORPHISM OF THE GENE OF THE INTERLEUKIN FAMILY C174G (RS1800795) IL6 IN THE DEVELOPMENT OF ACNE INFLAMMATION

Malikova N.N. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Arifov S.S. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Boboev K.T. - Republican Specialized Scientific and Practical Medical Hematology Center

Resume

In the pathogenesis of acne, inflammation plays an important role and its regulation is a major key aspect of treatment. Cutibacterium acnes bacteria (Propionibacterium acnes), by interacting with TLR-2 receptors, can stimulate the secretion of cytokines such as interleukin-6 (IL-6) and IL-8 by follicular keratinocytes, as well as IL-8 and IL-12 macrophages, which promote inflammation. Increased secretion of inflammatory cytokines has been found to be associated with IL6 (C174G) gene polymorphism. This study included 133 patients with acne of various degrees of severity and 125 conditionally healthy persons of Uzbek nationality, who were studied polymorphism rs1800795 gene Il6. As a result of our study, the risk of developing inflammation in carriers of allele G and genotypes G/G, C/G increases by 2-5 times, which makes the polymorphism rs1800795 an important predictor of acne, especially in severe cases.

Key words: acne, acne vulgaris, acne disease, IL6, gene polymorphism, cytokines, interleukins, inflammation, Cutibacterium acnes, sebaceous glands.

First page

161

Last page

165

For citation:Malikova N.N., Arifov S.S., Boboev K.T. - FEATURES OF POLYMORPHISM OF THE GENE OF THE INTERLEUKIN FAMILY C174G (RS1800795) IL6 IN THE DEVELOPMENT OF ACNE INFLAMMATION//New Day in Medicine 7(81)2025 161-165 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

List of References

1. Chen X, Min S, Chen C, Lin X, Wang D, Jiang G. Influence of RETN, IL-1, and IL-6 gene polymorphisms on the risk of acne vulgaris in the Chinese population. J Cosmet Dermatol. 2022 Oct;21(10):4965-4973. doi: 10.1111/jocd.14911. Epub 2022 Mar 21. PMID: 35279931;
2. Cong TX, Hao D, Wen X, Li XH, He G, Jiang X. From pathogenesis of acne vulgaris to anti-acne agents. Arch Dermatol Res. 2019 Jul;311(5):337-349. doi: 10.1007/s00403-019-01908-x. Epub 2019 Mar 11. PMID: 30859308
3. Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. 2020 Apr 1;10(1):5754. doi: 10.1038/s41598-020-62715-3. PMID: 32238884; PMCID: PMC7113252
4. Kurokawa I, Danby FW, Ju Q, Wang X, Xiang LF, Xia L, Chen W, Nagy I, Picardo M, Suh DH, Ganceviciene R, Schagen S, Tsatsou F, Zouboulis CC. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2009 Oct;18(10):821-32. doi: 10.1111/j.1600-0625.2009.00890.x. Epub 2009 Jun 23. PMID: 19555434
5. Malikova N, Karimov K, Boboev K, Arifov S. The CYP17A1 rs743572 gene polymorphism and risk of development and clinical features of Acne Vulgaris in the Uzbek population. Int J Biomed. 2019;9(2):125–7.
6. Oh Y, Hwang HJ, Yang H, Kim JH, Park JHY, Kim JE, Lee KW. Orobol, A Derivative of Genistein, Inhibits Heat-Killed Propionibacterium acnes-Induced Inflammation in HaCaT Keratinocytes. J Microbiol Biotechnol. 2020 Sep 28;30(9):1379-1386. doi: 10.4014/jmb.2003.03063
7. Ragab M, Hassan EM, Elneily D, Fathallah N. Association of interleukin-6 gene promoter polymorphism with acne vulgaris and its severity. Clin Exp Dermatol. 2019 Aug;44(6):637-642. doi: 10.1111/ced.13864. Epub 2019 Jan 16. PMID: 30652337
8. Younis S, Javed Q. The interleukin-6 and interleukin-1A gene promoter polymorphism is associated with the pathogenesis of acne vulgaris. Arch Dermatol Res. 2015 May;307(4):365-70. doi: 10.1007/s00403-014-1519-x. Epub 2014 Nov 29. PMID: 25432444;
9. Zhang H, Zhang Z. Genetic Variants Associated with Acne Vulgaris. Int J Gen Med. 2023 Aug 28;16:3843-3856. doi: 10.2147/IJGM.S421835. PMID: 37662507; PMCID: PMC10473401
10. Zouboulis CC, Jourdan E, Picardo M. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. J Eur Acad Dermatol Venereol. 2014 May;28(5):527-32. doi: 10.1111/jdv.12298. Epub 2013 Oct 18. PMID: 24134468

    file

    download