37 -7 (81) 2025 - Ruzikulov O.Sh., Dursunov A.M. - THE EFFECTIVENESS OF ULTRASOUND IN ACCELERATING BONE FRACTURE HEALING

THE EFFECTIVENESS OF ULTRASOUND IN ACCELERATING BONE FRACTURE HEALING

Ruzikulov O.Sh. - Republican Specialized Traumatology and Orthopedics Scientific and Practical Medical Center

Dursunov A.M. - Samarkand branch Republican Specialized Scientific and Practical Medical Center of Traumatology and Orthopedics

Jurayev I.G. - Samarkand State Medical University

Mannonov A.A. - Republican Specialized Traumatology and Orthopedics Scientific and Practical Medical Center

Resume

Low-intensity pulsed ultrasound (LIPUS) is an emerging technology that has been shown to enhance the fracture healing process with minimal thermal effects. This non-invasive treatment accelerates bone formation through various molecular, biological, and biomechanical interactions with tissues and cells. Although LIPUS treatment has demonstrated beneficial effects on different bone fracture sites, very few studies have investigated its effects on deeper bones. LIPUS is a type of ultrasound that is transmitted into connective tissues as an acoustic wave. As a non-invasive therapy, LIPUS has been utilized to promote fracture healing for 30 years and is the subject of numerous clinical studies. LIPUS can stimulate the differentiation of bone-forming cells, which contribute to bone formation, fracture healing, and the recovery of strength at the healing site. It has been established that LIPUS can promote the formation of the medullary canal and cortex in a gap-healing model, leading to earlier restoration of the structural integrity of the healing site. Many clinical studies indicate that LIPUS can enhance the healing of fresh fractures, delayed unions, nonunions, distraction osteogenesis, and congenital pseudoarthroses

Key words. Ultrasound, fracture healing, nonunion, osteogenesis

First page

186

Last page

190

For citation:Ruzikulov O.Sh., Dursunov A.M., Jurayev I.G., Mannonov A.A. - THE EFFECTIVENESS OF ULTRASOUND IN ACCELERATING BONE FRACTURE HEALING//New Day in Medicine 7(81)2025 186-190 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

List of References

  1. Pohlman R, Richter R, Parow E. Uber die Ausbreitung und Absorption des Ultraschalls in menschlichen Gewebe und seine therapeutische Wirkung an Ischia und Plexusneuralgie. Dtsch Med Wochenschr 1939; 65:251–254.
  2. Schortinghuis J, Stegenga B, Raghoebar GM, de Bont LG. Ultra sound stimulation of maxillofacial bone healing. Crit Rev Oral Biol Med 2003; 14:63–74.
  3. Buchtala V. Die ultraschallwirkung auf den wachsenden knochen; ergebnisse tierexperimenteller untersuchungen a jungen hunden. Strahlentherapie 1948; 78:127–142. 22.
  4. Barth G, Bülow H. Zur frage der ultraschallschädigung jugendlicher knochen. Strahlentherapie 1949; 79:98. 23. Bender LF, Janes JM, Herrick JF. Histologic studies following exposure of bone to ultrasound. Arch Phys Med Rehabil 1954; 35: 555–559.
  5. Ardan JRNI, Janes JM, Herrick J. Ultrasonic energy and surgically produced defects in bone. JBJS 1957; 39:394–402.
  6. Buchtala V. Present state of ultrasound therapy. Dia Med 1950; 22:2944–2950.
  7. Maintz G. Animal experiments in the study of the effect of ultra sonic waves on bone regeneration. Strahlentherapie 1950; 82: 631–638.
  8. Corradi C, Cozzolino A. Azione degli ultrasuoni sulla evoluzione delle fratture sperimentali dei conigli. Minerva Ortop 1952; 3: 44–45.
  9. Shiro I. Study on the ultrasonic irradiation in orthopedic surgery. Hirosaki Med 1964; 16:242–253.
  10. Yang Q, Nanayakkara GK, Drummer C, et al. Low-intensity ultrasound-induced anti-inflammatory effects are mediated by several new mechanisms including gene induction, immunosuppressor cell promotion, and enhancement of exosome biogenesis and docking. Front Physiol 2017; 8:818.

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