40 -7 (81) 2025 - Avezova G.S. - DIAGNOSTIC CHALLENGES AND EVOLVING APPROACHES IN SCHÖNLEIN - HENOCH PURPURA AMONG CHILDREN

DIAGNOSTIC CHALLENGES AND EVOLVING APPROACHES IN SCHÖNLEIN - HENOCH PURPURA AMONG CHILDREN

Avezova G.S. - Tashkent State Medical University

Resume

Henoch-Schönlein Purpura (HSP), or IgA vasculitis, is the most prevalent small-vessel vasculitis in the pediatric population, with variable clinical manifestations including palpable purpura, arthralgia, abdominal pain, and renal involvement. Despite the widespread use of the EULAR/PRINTO/PRES criteria, current diagnostic strategies often fall short in atypical or renal-predominant cases. This review critically examines global diagnostic approaches, highlighting traditional clinical criteria, laboratory biomarkers, imaging modalities, and histopathological confirmation methods. Furthermore, it explores emerging tools such as urinary cytokines, immunogenetic markers, and machine learning-based diagnostic algorithms. By synthesizing findings from recent studies, this review emphasizes the need for standardized, evidence-based, and regionally adaptable diagnostic models to improve early detection and personalized care in children with HSP

Keywords: Henoch-Schönlein Purpura (HSP); IgA vasculitis; pediatric vasculitis; diagnosis; renal biopsy; biomarkers; IL-17; immunogenetics; EULAR/PRINTO/PRES criteria; nephritis; machine learning; urinary cytokines

First page

199

Last page

207

For citation:Avezova G.S. - DIAGNOSTIC CHALLENGES AND EVOLVING APPROACHES IN SCHÖNLEIN - HENOCH PURPURA AMONG CHILDREN//New Day in Medicine 7(81)2025 199-207 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

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