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  • 54 -7 (81) 2025 - Saidov A.A. - CHANGES IN THE MORPHOMETRIC STATE OF SPLENIC LYMPHOID TISSUE UNDER CONDITIONS OF POLYPHARMACY

54 -7 (81) 2025 - Saidov A.A. - CHANGES IN THE MORPHOMETRIC STATE OF SPLENIC LYMPHOID TISSUE UNDER CONDITIONS OF POLYPHARMACY

CHANGES IN THE MORPHOMETRIC STATE OF SPLENIC LYMPHOID TISSUE UNDER CONDITIONS OF POLYPHARMACY

Saidov A.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Polypharmacy, characterized by the simultaneous use of multiple medications, has become a growing concern due to its potential negative effects on various organs, including the lymphoid tissues of the spleen. This study aimed to evaluate the morphometric changes in splenic lymphoid tissue under experimentally modeled polypharmacy conditions. Wistar rats were administered combinations of commonly used pharmacological agents over a defined period. Histological and morphometric analysis of splenic tissue revealed significant alterations in the size and structure of lymphoid follicles, marginal zones, and the red pulp. These changes suggest that polypharmacy can impair immune organ architecture, potentially compromising immune competence. The findings highlight the importance of evaluating immune system effects in patients receiving multiple drug regimens

Keywords: polypharmacy, spleen, lymphoid tissue, immune system, morphometry, histology, drug-induced changes

First page

274

Last page

277

For citation:Saidov A.A. - CHANGES IN THE MORPHOMETRIC STATE OF SPLENIC LYMPHOID TISSUE UNDER CONDITIONS OF POLYPHARMACY//New Day in Medicine 7(81)2025 274-277 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

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