68 -7 (81) 2025 - Khaydarova N.M. - MORPHOLOGICAL AND MORPHOMETRIC CHANGES IN MAJOR SALIVARY GLANDS AFTER EXPERIMENTAL CHEMOTHERAPY

MORPHOLOGICAL AND MORPHOMETRIC CHANGES IN MAJOR SALIVARY GLANDS AFTER EXPERIMENTAL CHEMOTHERAPY

Khaydarova N.M. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This study analyzed the morphological and morphometric changes occurring in the major salivary glands (parotid and submandibular glands) under the influence of experimental chemotherapy. A chemotherapy model was developed using cisplatin in six-month-old white outbred rats, and the resulting changes were assessed using histological and morphometric methods. The findings demonstrated a significant disruption in the secretory function and tissue structure of the salivary glands following chemotherapy. Chemotherapy is a chemical treatment method that involves the use of drugs with cytotoxic effects against malignant tumors. The drugs used in chemotherapy can induce various changes in the salivary glands. Therefore, this study investigated the morphological alterations in the tissue of major salivary glands resulting from chemotherapy for breast cancer

Keywords: chemotherapy, salivary gland, morphology, morphometry, cisplatin

First page

357

Last page

362

For citation:Khaydarova N.M. - MORPHOLOGICAL AND MORPHOMETRIC CHANGES IN MAJOR SALIVARY GLANDS AFTER EXPERIMENTAL CHEMOTHERAPY//New Day in Medicine 7(81)2025 357-362 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

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