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80 -7 (81) 2025 - Ismatova M.M., Teshaev Sh.Zh. - THE EFFECT OF ENERGY DRINKS ON THE MORPHOFUNCTIONAL STATE OF THE OVARIES IN ADOLESCENT GIRLS

THE EFFECT OF ENERGY DRINKS ON THE MORPHOFUNCTIONAL STATE OF THE OVARIES IN ADOLESCENT GIRLS

Ismatova M.M. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Teshaev Sh.Zh. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Dustova N.K. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The aim of the study was to determine the effect of regular consumption of energy drinks on the morphological state of the ovaries and reproductive function in adolescent girls, based on clinical, laboratory and experimental data. Methods: a combined experimental and clinical study was conducted. In the experimental part, 30 sexually mature female rats were divided into groups: a control group that received a regular diet, and experimental groups that were given a daily non-alcoholic energy drink (containing caffeine ~ 3.2 mg/ 100 g and taurine ~40 mg/100 g of body weight) for 90 days; one of the groups additionally received a protective agent (Nigella sativa oil). Histological and immunohistochemical analysis of the ovaries was performed. In the clinical part, 63 girls aged 16-18 were examined (30 regularly consumed energy for ≥3 months, 33 were controls without stimulants). All underwent ultrasound examination of the ovaries and determination of the hormonal profile (anti–muller hormone - AMH, gonadotropins, estradiol, progesterone, prolactin). Main results: in rats systematically treated with energetics, pronounced pathomorphological changes of the ovaries were revealed: a decrease in the number of growing follicles, signs of cystic atresia, thickening of the protein capsule and focal fibrosis of the stroma compared with the control. In adolescents who consumed energy drinks, only 70% maintained a regular ovulatory cycle (versus 91% in the control, p<0.05); menstrual cycle disorders were observed 5-6 times more often, including oligomenorrhea and intermenstrual bleeding. The average AMH level in the main group was significantly lower than the control (1.32±0.45 ng/ml versus 2.08±0.51 ng/ml, p<0.001), with a simultaneous increase in FSH and especially LH (by ~30%, p<0.01). 56.7% of the girls in the main group had a reduced ovarian reserve (AMH <1.5 ng/ml) is ~5.8 times more common than in non–users (HR=5.8; p=0.0014). Ultrasound imaging of the ovaries in energy users was characterized by an increase in the average volume of the ovaries (≈9.9 vs. 8.0 cm3, p<0.001), multiple small follicles (multifollicular ovaries – 36.7% vs. 12.1%, p<0.05) and functional cysts (30% vs. 6%, p<0.01). Scientific novelty: for the first time, a comprehensive description of the effect of energy drink components on the reproductive system of adolescent girls has been given. It has been shown that the systematic use of energy drinks leads to a combination of cystic-dystrophic changes in the ovaries and hormonal imbalance, indicating an inhibition of ovulatory function and a decrease in ovarian reserve in adolescents

Keywords: energy drinks, adolescents, reproductive system, ovaries, hormonal status, ovarian reserve, anti-muller hormone

First page

427

Last page

439

For citation:Ismatova M.M., Teshaev Sh.Zh., Dustova N.K. - THE EFFECT OF ENERGY DRINKS ON THE MORPHOFUNCTIONAL STATE OF THE OVARIES IN ADOLESCENT GIRLS//New Day in Medicine 7(81)2025 427-439 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

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