94 -7 (81) 2025 - Yodgorov N.A., Makhkamov N.Zh. - PATHOMORPHOLOGY OF DECREASED COLLAGEN TYPE IV EXPRESSION IN CRUCIATE LIGAMENT TISSUES IN POST-TRAUMATIC GONARTHROSIS

PATHOMORPHOLOGY OF DECREASED COLLAGEN TYPE IV EXPRESSION IN CRUCIATE LIGAMENT TISSUES IN POST-TRAUMATIC GONARTHROSIS

Yodgorov N.A. - Fergana Medical Institute of Public Health Fergana region

Makhkamov N.Zh. - Andijan State Medical Institute

Resume

This article presents a pathomorphological analysis of the decreased expression of collagen type IV in cruciate ligament tissues in post-traumatic gonarthrosis. Cruciate ligaments are essential structures responsible for maintaining the mechanical stability of the knee joint. Collagen type IV is a major component of the extracellular matrix and plays a significant role in tissue trophism and regeneration. The study revealed a marked reduction in collagen IV expression in the cruciate ligaments under post-traumatic conditions, accompanied by fibrosis, hyalinization, and impaired microvascularization. These structural alterations may contribute to the functional deterioration of the ligaments and the progression of gonarthrosis

Keywords: post-traumatic gonarthrosis, cruciate ligament, collagen type IV, pathomorphology, fibrosis, extracellular matrix

First page

503

Last page

507

For citation:Yodgorov N.A., Makhkamov N.Zh. - PATHOMORPHOLOGY OF DECREASED COLLAGEN TYPE IV EXPRESSION IN CRUCIATE LIGAMENT TISSUES IN POST-TRAUMATIC GONARTHROSIS//New Day in Medicine 7(81)2025 503-507 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

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