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  • 106 -7 (81) 2025 - Radjbova Z.A., Karimova F.D. - CLINICAL, ANAMNESTIC, AND GENETIC PREDICTORS OF SEVERE PREECLAMPSIA AS A FORM OF SECONDARY THROMBOTIC MICROANGIOPATHY IN PREGNANT WOMEN

106 -7 (81) 2025 - Radjbova Z.A., Karimova F.D. - CLINICAL, ANAMNESTIC, AND GENETIC PREDICTORS OF SEVERE PREECLAMPSIA AS A FORM OF SECONDARY THROMBOTIC MICROANGIOPATHY IN PREGNANT WOMEN

CLINICAL, ANAMNESTIC, AND GENETIC PREDICTORS OF SEVERE PREECLAMPSIA AS A FORM OF SECONDARY THROMBOTIC MICROANGIOPATHY IN PREGNANT WOMEN

Radjbova Z.A. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Karimova F.D. - Center for the Development of Professional Qualifications of Medical Workers under the Ministry of Health of the Republic of Uzbekistan

Resume

Objective: The aim of this study is to analyze the clinical-demographic characteristics, latent risk factors, and genetic predictors of severe preeclampsia (sPE) as a form of secondary thrombotic microangiopathy (TMA). Methods: The study was conducted on a cohort of 327 patients with sPE, representing 87.4% of all TMA cases in the study population, and a control group of 50 women with physiologically normal pregnancies. The research involved a detailed analysis of medical history, clinical and laboratory parameters, obstetric outcomes, and the prevalence of thrombophilia-associated gene polymorphisms, including F5 Leiden (G1691A), F2 (G20210A), MTHFR (C677T, A1298C), and AGTR1/AGTR2. Results: It was established that sPE is characterized by earlier gestational age at delivery, lower birth weight and length of newborns, elevated liver enzymes, hemolytic anemia, and thrombocytopenia. Genetic analysis revealed a high carriage rate of mutant alleles for F5 Leiden and MTHFR C677T among patients with sPE, confirming the role of inherited thrombophilia in the pathogenesis of this complication. Conclusion: The identified clinical and genetic associations underscore the necessity for early screening of pregnant women for thrombophilias and more aggressive dynamic monitoring in high-risk groups to prevent life-threatening complications

Keywords: Preeclampsia, thrombotic microangiopathy, pregnancy, thrombophilia, F5 Leiden, MTHFR C677T, obstetric complications, placental insufficiency

First page

561

Last page

565

For citation:Radjbova Z.A., Karimova F.D. - CLINICAL, ANAMNESTIC, AND GENETIC PREDICTORS OF SEVERE PREECLAMPSIA AS A FORM OF SECONDARY THROMBOTIC MICROANGIOPATHY IN PREGNANT WOMEN//New Day in Medicine 7(81)2025 561-565 https://newdayworldmedicine.com/en/new_day_medicine/7-81-2025

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