6 -8 (82) 2025 - Rakhimov B.A., Khamdamov B.Z. - CLINICAL AND PATHOGENETIC RELATIONSHIP BETWEEN IMMUNOLOGICAL CHANGES IN THE PERIOPERATIVE PERIOD IN CANCER PATIENTS

CLINICAL AND PATHOGENETIC RELATIONSHIP BETWEEN IMMUNOLOGICAL CHANGES IN THE PERIOPERATIVE PERIOD IN CANCER PATIENTS

Rakhimov B.A. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Khamdamov B.Z. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

As a result of the complex analysis, a systemic interdependence was established between the nature of the perioperative immune response, the type of anesthesia and the probability of the formation of an immunosuppressive state. The data obtained allow us to build a substantiated pathogenetic model in which the anesthetic effect acts not as a neutral component of pain relief, but as an active modifier of the immune balance in the conditions of an oncological disease

Keywords: oncology, surgery, anesthesia, immunity

First page

32

Last page

36

For citation:Rakhimov B.A., Khamdamov B.Z. - CLINICAL AND PATHOGENETIC RELATIONSHIP BETWEEN IMMUNOLOGICAL CHANGES IN THE PERIOPERATIVE PERIOD IN CANCER PATIENTS//New Day in Medicine 8(82)2025 32-36 https://newdayworldmedicine.com/en/new_day_medicine/8-82-2025

List of References

  1. Belyaev AM, Baldueva IA, Prokhorov GG, et al. Immunological changes in patients with malignant neoplasms after cryogenic and ultrasound ablation of the tumor // Issues of oncology. - 2017. - Vol. 63, No. 1. - Pp. 14-18. - EDN YHPYWH.
  2. Zagidullina ER, Zdorov GS, Korsunskaya AI, et al. Immune-mediated adverse reactions during therapy with immune checkpoint inhibitors // Medicine. Sociology. Philosophy. Applied research. - 2025. - No. 2. - Pp. 53-57. - EDN APQMAY
  3. Mozgovoy VA, Korsunsky DA, Belyaev AV The Impact of Surgical Stress on the Immune Response // Russian Medical Journal. - 2018. - Vol. 26, No. 2. - P. 17-22. 4. Polyakova E. A., Guryanova I. E., Vertelko V. R., et al. Use of Next-Generation Sequencing Technologies in the Diagnosis of Congenital Errors of the Immune System // Issues of Hematology/Oncology and Immunopathology in Pediatrics. - 2023. - Vol. 22, No. 3. - P. 177-184. - DOI: 10.24287/1726-1708-2023-22-3-177-184. – EDN XXPVYS
  4. Fassakhov A. R., Smolin A. V., Konev A. V., et al. The role of immunotherapy in the treatment of advanced small cell lung cancer // Medical Bulletin of the Burdenko Main Military Clinical Hospital. – 2021. – No. 2(4). – P. 40–45. – EDN ILBIXZ.
  5. Aboalsoud A., El-Ghaiesh S. H., Elmonem F. F. A., et al. The effect of low-dose naltrexone on solid Ehrlich carcinoma in mice: The role of OGFr, BCL2, and immune response // Int Immunopharmacol. – 2020. – Vol. 78. – Article 106068. – DOI: 10.1016/j.intimp.2019.106068
  6. Al-Mozain N., Arora S., Goel R., et al. Patient blood management in adults and children: What have we achieved, and what still needs to be addressed? // Transfus Clin Biol. – 2023. – Vol. 30. – P. 355–359. – DOI: 10.1016/j.tracli.2023.03.005.
  7. Bezu L., Bordenave L., Suria S., et al. Onco-anaesthesia: From theory to practice // Anesth Reanim. – 2022. – Vol. 8. – P. 315–330.
  8. Bezu L., Kepp O., Kroemer G., et al. Local anesthetics and immunotherapy: a novel combination to fight cancer // Semin. Immunopathol. – 2023. – Vol. 45, No. 3. – P. 265–272. – DOI: 10.1007/s00281-022-00960-6

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