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  • 67 -8 (82) 2025 - Muminov A.Sh., Valiev E.Y., - CLINICAL AND IMMUNOLOGICAL MODEL FOR PREDICTING COMPLICATIONS AFTER LARGE BONE FRACTURES

67 -8 (82) 2025 - Muminov A.Sh., Valiev E.Y., - CLINICAL AND IMMUNOLOGICAL MODEL FOR PREDICTING COMPLICATIONS AFTER LARGE BONE FRACTURES

CLINICAL AND IMMUNOLOGICAL MODEL FOR PREDICTING COMPLICATIONS AFTER LARGE BONE FRACTURES

Muminov A.Sh. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Valiev E.Y. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Khamdamov B.Z. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

In result, fractures of major bones (pelvis, femur, tibia) were confirmed to carry high risks of infection, thromboembolism, and nonunion. Retrospective analysis of 284 cases identified clinical and immunological predictors, leading to a risk model of 8 variables (injury type, IL-2, TNF-α, D-dimer). In a prospective cohort of 124 patients, applying this model with personalized prophylaxis, including CO₂ therapy, reduced complications from 45% to 21.8%, prevented fatal pulmonary emboli, and improved recovery (Majeed 84 vs 68). The model enables reliable risk stratification and early targeted interventions.

Keywords: bone fractures; complications; risk prediction; immunological markers; venous thromboembolism; CO₂ therapy

First page

373

Last page

380

For citation:Muminov A.Sh., Valiev E.Y., Khamdamov B.Z. - CLINICAL AND IMMUNOLOGICAL MODEL FOR PREDICTING COMPLICATIONS AFTER LARGE BONE FRACTURES//New Day in Medicine 8(82)2025 373-380 https://newdayworldmedicine.com/en/new_day_medicine/8-82-2025

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