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  • 21 -9 (83) 2025 - Yuldashev T.A. - MODERN APPROACHES AND ONGOING CHALLENGES IN MANAGING CLEFT LIP AND PALATE PATIENTS: A COMPREHENSIVE REVIEW

21 -9 (83) 2025 - Yuldashev T.A. - MODERN APPROACHES AND ONGOING CHALLENGES IN MANAGING CLEFT LIP AND PALATE PATIENTS: A COMPREHENSIVE REVIEW

MODERN APPROACHES AND ONGOING CHALLENGES IN MANAGING CLEFT LIP AND PALATE PATIENTS: A COMPREHENSIVE REVIEW

Yuldashev T.A. - Alfraganus University

Resume

Cleft lip and cleft palate represent some of the most prevalent congenital malformations of the oral cavity, with incidence rates varying across populations. Their etiology is multifactorial, influenced by both genetic predispositions and environmental factors. The objective of this narrative review is to examine the pediatric population with cleft lip and/or palate as a primary focus for interdisciplinary treatment. This review summarizes current knowledge on treatment approaches for cleft patients and underscores the essential need for close collaboration among dental specialists and medical professionals. Effective management requires the combined expertise of oral surgeons, prosthodontists, orthodontists, pediatricians, speech therapists, phoniatricians, and otolaryngologists to ensure comprehensive care.

Keywords: cleft lip, cleft palate, interdisciplinary treatment, orthodontics, pediatric care.

First page

121

Last page

130

For citation:Yuldashev T.A. - MODERN APPROACHES AND ONGOING CHALLENGES IN MANAGING CLEFT LIP AND PALATE PATIENTS: A COMPREHENSIVE REVIEW//New Day in Medicine 9(83)2025 121-130 https://newdayworldmedicine.com/en/new_day_medicine/9-83-2025

List of References

  1. Mossey P.A., Little J., Munger R.G., Dixon M.J., Shaw W.C. Cleft lip and palate. Lancet. 2009;374:1773–1785. doi: 10.1016/S0140-6736(09)60695-4. [DOI] [PubMed] [Google Scholar]
  2. Supplement D., Candotto V., Oberti L., Gabrione F., Greco G., Rossi D., Romano M., Mummolo S. Current concepts on cleft lip and palate etiology. J. Biol. Regul. Homeost. Agents. 2019;33:145–151. [PubMed] [Google Scholar]
  3. Cuozzo F.D.M., Espinosa M.M., Da Silva K.T.S., De Barros Y.B.A.M., Bandeca M.C., Aranha A.M.F., Borges A.H., Volpato L.E.R. Cleft lip and palate in a Brazilian subpopulation. J. Int. Oral Health. 2013;5:15–20. [PMC free article] [PubMed] [Google Scholar]
  4. Martinelli M., Palmieri A., Carinci F., Scapoli L. Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors. Front. Cell Dev. Biol. 2020;8:592271. doi: 10.3389/fcell.2020.592271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Crockett D.J., Goudy S.L. Cleft Lip and Palate. Facial Plast. Surg. Clin. N. Am. 2014;22:573–586. doi: 10.1016/j.fsc.2014.07.002. [DOI] [PubMed] [Google Scholar]
  6. Vyas T., Gupta P., Kumar S., Gupta R., Gupta T., Singh H.P. Cleft of lip and palate: A review. J. Fam. Med. Prim. Care. 2020;9:2621–2625. doi: 10.4103/jfmpc.jfmpc_472_20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rychlik D., Wojcicki P., Koźlik M. Osteoplasty of the alveolar cleft defect. Adv. Clin. Exp. Med. 2012;21:255–262. [PubMed] [Google Scholar]
  8. Brézulier D., Chaigneau L., Jeanne S., Lebullenger R. The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery. Biomedicines. 2021;9:1553. doi: 10.3390/biomedicines9111553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Raffaini M., Cocconi R., Spinelli G., Agostini T. Simultaneous Rhinoseptoplasty and Orthognathic Surgery: Outcome Analysis of 250 Consecutive Patients Using a Modified Le Fort I Osteotomy. Aesthetic Plast. Surg. 2018;42:1090–1100. doi: 10.1007/s00266-018-1121-2. [DOI] [PubMed] [Google Scholar] 10. Al-Namankany A., Alhubaishi A. Effects of cleft lip and palate on children’s psychological health: A systematic review. J. Taibah Univ. Med. Sci. 2018;13:311–318. doi: 10.1016/j.jtumed.2018.04.007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Grayson B.H., Maull D. Nasoalveolar molding for infants born with clefts of the lip, alveolus, and palate. Clin. Plast. Surg. 2004;31:149–158. doi: 10.1016/S0094-1298(03)00140-8. [DOI] [PubMed] [Google Scholar]
  11. Bhutiani N., Tripathi T., Verma M., Bhandari P.S., Rai P. Assessment of Treatment Outcome of Presurgical Nasoalveolar Molding in Patients with Cleft Lip and Palate and Its Postsurgical Stability. Cleft Palate Craniofac. J. 2020;57:700–706. doi: 10.1177/1055665620906293. [DOI] [PubMed] [Google Scholar]
  12. Koya S., Shetty S., Husain A., Khader M. Presurgical Nasoalveolar Molding Therapy Using Figueroa’s NAM Technique in Unilateral Cleft Lip and Palate Patients: A Preliminary Study. J. Clin. Pediatr. Dent. 2016;40:410–416. doi: 10.17796/1053-4628-40.5.410. [DOI] [PubMed] [Google Scholar]
  13. De Oliveira N.V., Tou G.A.A., Silva R.S., Rezende S.E., Pretti H., Macari S. The First-Year Follow-Up of a Cleft Lip and Palate Patient Treated with Nasoalveolar Molding (NAM) Braz. Dent. J. 2020;31:190–196. doi: 10.1590/0103-6440202003040. [DOI] [PubMed] [Google Scholar]
  14. Ruíz-Escolano M.G., Martínez-Plaza A., Fernández-Valadés R., Cortés-Sánchez R., Muñoz-Miguelsanz M.A., Velasco-Ortega E., Perez-Ureña M.B., Matar-Satuf K., España-López A.J. Nasoalveolar Molding Therapy for the Treatment of Unilateral Cleft Lip and Palate Improves Nasal Symmetry and Maxillary Alveolar Dimensions. J. Craniofac. Surg. 2016;27:1978–1982. doi: 10.1097/SCS.0000000000003047. [DOI] [PubMed] [Google Scholar]
  15. Papadopoulos M.A., Koumpridou E.N., Vakalis M.L., Papageorgiou S.N. Effectiveness of pre-surgical infant orthopedic treatment for cleft lip and palate patients: A systematic review and meta-analysis. Orthod. Craniofac. Res. 2012;15:207–236. doi: 10.1111/j.1601-6343.2012.01552.x. [DOI] [PubMed] [Google Scholar]
  16. Worley M.L., Patel K.G., Kilpatrick L.A. Cleft Lip and Palate. Clin. Perinatol. 2018;45:661–678. doi: 10.1016/j.clp.2018.07.006. [DOI] [PubMed] [Google Scholar]
  17. Jung S., Chung K.H., Chang S.-Y., Ohrmman D., Lim E., Lo L.-J. A new technique for perioral muscle reconstruction and lip lengthening in complete unilateral cleft lip. J. Plast. Reconstr. Aesthetic Surg. 2020;73:749–757. doi: 10.1016/j.bjps.2019.11.013. [DOI] [PubMed] [Google Scholar]
  18. Raghavan U., Rao D., Ullas G., Vijayadev V. Postoperative Management of Cleft Lip and Palate Surgery. Facial Plast. Surg. 2018;34:605–611. doi: 10.1055/s-0038-1676381. [DOI] [PubMed] [Google Scholar]
  19. Kobus K., Kobus-Zaleśna K. Timing of cleft lip and palate repair. Dev. Period Med. 2014;18:79–83. [PubMed] [Google Scholar]

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