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  • 33 -9 (83) 2025 - Rabbimova D.T., Shavdirova G.M. - CLINICAL SIGNIFICANCE OF FECAL CALPROTECTIN IN ANTIBIOTIC-ASSOCIATED DIARRHEA IN EARLY CHILDHOOD

33 -9 (83) 2025 - Rabbimova D.T., Shavdirova G.M. - CLINICAL SIGNIFICANCE OF FECAL CALPROTECTIN IN ANTIBIOTIC-ASSOCIATED DIARRHEA IN EARLY CHILDHOOD

CLINICAL SIGNIFICANCE OF FECAL CALPROTECTIN IN ANTIBIOTIC-ASSOCIATED DIARRHEA IN EARLY CHILDHOOD

Rabbimova D.T. - Samarkand State Medical University

Shavdirova G.M. - Samarkand State Medical University

Resume

Objective. To evaluate the clinical significance of fecal calprotectin in the course of antibiotic-associated diarrhea (AAD) in early childhood, with a focus on distinguishing infectious and non-infectious forms and assessing its role as a diagnostic marker. Materials and Methods. A prospective study was conducted at the Samarkand State Medical University and the Samarkand Multidisciplinary Pediatric Medical Center between 2023 and 2025. A total of 140 children aged 1 month to 3 years with clinically confirmed AAD after antibacterial therapy were included. Fecal calprotectin levels were determined using ELISA and compared across groups: Clostridioides difficile-associated AAD (Cl+), AAD caused by other bacteria, non-infectious AAD, and a healthy control group. Statistical analysis was performed using χ² tests, odds ratios (OR), and p-values. Results. Fecal calprotectin levels were highest in the Cl+ group (393.65 ± 39.23 μg/g), indicating marked intestinal neutrophilic inflammation. Children with bacterial AAD due to other pathogens had moderately elevated levels (195.45 ± 24.49 μg/g; p₁=0.0001 vs. Cl+), while the non-infectious AAD group showed significantly lower values (85.2 ± 11.7 μg/g; p₂=0.0001 vs. Cl+). In healthy controls, calprotectin remained within the normal range (31.6 ± 3.82 μg/g; p<0.001 vs. all AAD groups). No direct correlation was found between the severity of the underlying disease and AAD severity, supporting the role of calprotectin as an independent marker. Conclusion. Fecal calprotectin is a sensitive and non-invasive biomarker of intestinal inflammation in young children with AAD. It allows differentiation between infectious and non-infectious forms, with the highest diagnostic value observed in Cl.difficile-associated cases. Incorporating fecal calprotectin measurement into clinical practice may improve risk stratification and treatment decisions in pediatric AAD.

Keywords: antibiotic-associated diarrhea, young children, Cl.difficile, fecal calprotectin, clinical marker.

First page

206

Last page

209

For citation:Rabbimova D.T., Shavdirova G.M. - CLINICAL SIGNIFICANCE OF FECAL CALPROTECTIN IN ANTIBIOTIC-ASSOCIATED DIARRHEA IN EARLY CHILDHOOD//New Day in Medicine 9(83)2025 206-209 https://newdayworldmedicine.com/en/new_day_medicine/9-83-2025

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