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  • 25 -2 (40) 2022 — Musabaev E.I., Oblokulov A.A. — THE SIGNIFICANCE OF THE LEVEL OF PROCALCITONIN IN THE BLOOD SERUM FOR EARLY DIAGNOSIS OF SPONTANEOUS BACTERIAL PERITONITIS IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS OF VIRAL ETIOLOGY

25 -2 (40) 2022 — Musabaev E.I., Oblokulov A.A. — THE SIGNIFICANCE OF THE LEVEL OF PROCALCITONIN IN THE BLOOD SERUM FOR EARLY DIAGNOSIS OF SPONTANEOUS BACTERIAL PERITONITIS IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS OF VIRAL ETIOLOGY

THE SIGNIFICANCE OF THE LEVEL OF PROCALCITONIN IN THE BLOOD SERUM FOR EARLY DIAGNOSIS OF SPONTANEOUS BACTERIAL PERITONITIS IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS OF VIRAL ETIOLOGY

Musabaev E.I. Scientific Research Institute of Virology of the Ministry of Health of the Republic of Uzbekistan

Oblokulov A.A. Bukhara State Medical Institute. Abu Ali ibn Sino

Resume

120 [64 (53.3%) men and 56 (46.7%) women] patients with cirrhosis of the liver of viral etiology at the age from 30 to 69 years were examined. Of the clinical symptoms, the most common signs of SBP were fever – 36.7%, leukocytosis with the appearance of immature forms of leukocytes – 46.7%, dyspeptic symptoms – 61.7%.

In all patients with SBP (n = 60) who emerged in the phase of decompensation of viral cirrhosis, PCT levels were significantly (p = 0.001) higher than in patients of the second group, that is, in uncomplicated patients with SBP (n = 60). When analyzing an increase in the PCT level in blood serum in patients of the first group, the PCT content was observed in the range of 0.5-1.0 ng / ml in 45.0%, in the range of 1.0-2.0 ng / ml in 28.3% and in the range> 2.0 ng / ml in 26.7% of patients. In the second group of observed patients, serum PCT did not exceed 0.2 ng / ml. PCT levels in blood serum were recorded in the range of 0.05–0.1 ng / ml in 18.5% of patients, in the range of 0.1–0.25 ng / ml in 30.0% of patients and in the range 0.25– 0.5 ng / ml in 51.7% of patients.

Key words: cirrhosis, spontaneous bacterial peritonitis, procalcitonin

First page

129

Last page

134

For citation: Musabaev E.I., Oblokulov A.A. THE SIGNIFICANCE OF THE LEVEL OF PROCALCITONIN IN THE BLOOD SERUM FOR EARLY DIAGNOSIS OF SPONTANEOUS BACTERIAL PERITONITIS IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS OF VIRAL ETIOLOGY //New Day in Medicine 2(40)2022 129-134 https://cutt.ly/DAkl0Jt

LIST OF REFERENCES:

  1. Ginès P., Fernández J., Durand F., Saliba F. Management of critically ill cirrhotic patients. //J Hepatol. 2012; 56 Suppl 1:S13–24., 
  2. Galbois A, Aegerter P, Martel-Samb P, Housset C, Thabut D, Offenstadt G, et al. Improved prognosis of septic shock in patients with cirrhosis: a multicenter study. //Crit Care Med. 2014; 42:1666–75.
  3. Jalan R., Fernandez J., Wiest R., Schnabl B., Moreau R., Angeli P., et al. Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol. 2014; 60:1310–24.
  4. Shalimar, Acharya SK. Difficult to treat spontaneous bacterial peritonitis. Trop Gastroenterol. 2013; 34:7–13.
  5. Oblokulov A.A. (2020) Clinical and epidemiological characteristics of spontaneous bacterial peritonitis in cirrosis of hepatic viral etiology// New Day in Medicine №3 (31):423-425.
  6. Campillo B., Richardet J.P., Kheo T., Dupeyron C. Nosocomial spontaneous bacterial peritonitis and bacteremia in cirrhotic patients: impact of isolate type on prognosis and characteristics of infection. Clin Infect Dis. 2002;35:1–10.
  7. Jalan R., Fernandez J., Wiest R., Schnabl B., Moreau R., Angeli P. et al (2014) Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol 60:1310–1324.
  8. Cai, Z.H., Fan, C.L., Zheng, J.F. et al. Measurement of serum procalcitonin levels for the early diagnosis of spontaneous bacterial peritonitis in patients with decompensated liver cirrhosis. BMC Infect Dis 15,55 (2015). https://doi.org/10.1186/s12879-015-0776-4. 
  9. Oblokulov A.A., Oblokulov A.R., & Ergashov M.M. (2021). Clinical And Laboratory Criteria For Spontaneous Bacterial Peritonitis In Liver Cirrosis Of Viral Etiology. CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES, 2(1), 172-177. https://doi.org/10.47494/cajmns.v2i1.99
  10. Uzzan B., Cohen R., Nicolas P., Cucherat M., Perret G.Y. (2006) Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 34(7):1996–2003.
  11. Abdurashid Rahimovich Oblokulov, Zilola Zohirovna Husenova, Maksudjon Muzaffarovich Ergashev. (2021). Procalcitonin as an Indicator of Antibacterial Therapy in Covid-19. Annals of the Romanian Society for Cell Biology, Volume 25: Issue 3. 5220–5224.
  12. Cai Z.H., Fan C.L., Zheng J.F., Zhang X., Zhao W.M., Li B. et al (2015) Measurement of serum procalcitonin levels for the early diagnosis of spontaneous bacterial peritonitis in patients with decompensated liver cirrhosis. BMC Infect Dis 15:55.

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