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  • 84 -8 (82) 2025 - Ulugbekova G.J., Mamajonov Z.A. - EFFECTS OF TRADITIONAL MEDICINE REMEDIES ON MACROPHAGES: A REVIEW OF CURRENT STUDIES

84 -8 (82) 2025 - Ulugbekova G.J., Mamajonov Z.A. - EFFECTS OF TRADITIONAL MEDICINE REMEDIES ON MACROPHAGES: A REVIEW OF CURRENT STUDIES

EFFECTS OF TRADITIONAL MEDICINE REMEDIES ON MACROPHAGES: A REVIEW OF CURRENT STUDIESG

Ulugbekova G.J. - Andijan State Medical Institute

Mamajonov Z.A. - Andijan State Medical Institute

Mamatova I.Y. - Andijan State Medical Institute

Resume

Macrophages are central cells of the immune response with the ability to repolarize between pro-inflammatory (M1) and reparative/anti-inflammatory (M2) phenotypes. Natural compounds widely used in traditional medicine (polyphenols, alkaloids, saponins, diterpenoids, etc.) modulate macrophage polarization through signaling pathways such as TLR4/NF-κB, MAPK, PI3K–AKT, AMPK, and PPARγ, showing promising outcomes in reducing inflammation and accelerating resolution in various diseases. Recent systematic reviews and experimental studies demonstrate that curcumin, EGCG, berberine, ginsenosides, astragaloside IV, andrographolide, and glycyrrhizic acid can selectively regulate the M1/M2 balance.

Keywords: macrophages, traditional medicine remedies, polyphenols, alkaloids, immunomodulation.

First page

479

Last page

483

For citation:Ulugbekova G.J., Mamajonov Z.A., Mamatova I.Y. - EFFECTS OF TRADITIONAL MEDICINE REMEDIES ON MACROPHAGES: A REVIEW OF CURRENT STUDIES//New Day in Medicine 8(82)2025 479-483 https://newdayworldmedicine.com/en/new_day_medicine/8-82-2025

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