82 -9 (83) 2025 - Ulugbekova G.J., Mamajonov Z.A. - MORPHOLOGY OF MACROPHAGES: THEORETICAL FOUNDATIONS AND EVALUATION CRITERIA

MORPHOLOGY OF MACROPHAGES: THEORETICAL FOUNDATIONS AND EVALUATION CRITERIA

Ulugbekova G.J. - Andijan State Medical Institute

Mamajonov Z.A. - Andijan State Medical Institute

Mamatova I.Y. - Andijan State Medical Institute

Resume

Macrophages are one of the key cells of the innate immune system, playing important roles in host defense, regulation of inflammation, and tissue repair. The morphological features of macrophages are closely related to their functional state, interaction with the microenvironment, and phenotypic polarization. Their shape, nuclear structure, cytoplasmic vacuoles, and organelle development are the main indicators used for morphological assessment. This article reviews the theoretical foundations of macrophage morphology, methods for their evaluation by light and electron microscopy, and the morphological distinctions between M1 and M2 phenotypes. The results of such studies may have practical applications in the diagnosis and therapy of cancer, autoimmune, and inflammatory diseases.

Keywords: macrophage, morphology, polarization, M1/M2, microscopy, evaluation criteria.

First page

506

Last page

508

For citation:Ulugbekova G.J., Mamajonov Z.A., Mamatova I.Y. - MORPHOLOGY OF MACROPHAGES: THEORETICAL FOUNDATIONS AND EVALUATION CRITERIA//New Day in Medicine 9(83)2025 506-508 https://newdayworldmedicine.com/en/new_day_medicine/9-83-2025

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