33 -10 (84) 2025 - M.E. Irismetov, A.A. Makhmudov - INFLUENCE OF OXIDATIVE STRESS GENES ON ASEPTIC NECROSIS OF THE FETAL HEAD

INFLUENCE OF OXIDATIVE STRESS GENES ON ASEPTIC NECROSIS OF THE FETAL HEAD

M.E. Irismetov - Republican Specialized Traumatology and Orthopedics Scientific and Practical Medical Center

A.A. Makhmudov - Republican Specialized Traumatology and Orthopedics Scientific and Practical Medical Center

A.M. Juraev - Republican Specialized Traumatology and Orthopedics Scientific and Practical Medical Center

Resume

Aseptic necrosis (AN) is a pathological condition resulting from impaired blood supply to bone tissue. Most often, it affects the head of the femur. This pathological process is characterized by bone tissue ischemia, disruption of cellular metabolism, and tissue necrosis. Recent international studies have shown that oxidative stress and antioxidant defense play a significant role in the pathogenesis of this disease. Oxidative stress occurs when there is excessive formation of active oxygen (AFS) and insufficient antioxidant protection, leading to cell damage. The key enzymes involved in this process are superoxide dismutase (SOD2), catalase (CAT), and glutathione peroxidase (GPX1). The polymorphisms of genes that influence the activity of these enzymes determine the body's resistance to oxidative stress. The results of this study are important for developing early diagnostic tools and personalized treatment strategies.

Keywords: aseptic necrosis, femoral head, oxidative stress, gene polymorphism, superoxide dismutase 2 (SOD2), endothelial nitrogen oxide synthetase (eNOS), catalase (CAT), glutathione peroxidase 1 (GPX1), antioxidants.

First page

177

Last page

182

For citation:M.E. Irismetov, A.A. Makhmudov, A.M. Juraev - INFLUENCE OF OXIDATIVE STRESS GENES ON ASEPTIC NECROSIS OF THE FETAL HEAD//New Day in Medicine 10(84)2025 177-182 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

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