36 -10 (84) 2025 - Teshaev Sh.J., Khabibullayev T.U. - AGE-RELATED MORPHOFUNCTIONAL ALTERATIONS IN TESTICULAR TISSUE OF OUTBRED WHITE RATS

AGE-RELATED MORPHOFUNCTIONAL ALTERATIONS IN TESTICULAR TISSUE OF OUTBRED WHITE RATS

Teshaev Sh.J. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Khabibullayev T.U. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

This study presents the results of an investigation into the morphofunctional characteristics of testicular tissue in 5-7 months -old outbred white rats under experimental rheumatoid arthritis. A comparative analysis of age-related changes in morphological structures and functional parameters of the tissue was carried out. It was found that the development of rheumatoid arthritis is accompanied by pronounced destructive alterations in the testes, the severity of which increases with the age of the animals. A decrease in the number of interstitial endocrinocytes, degenerative processes in the seminiferous tubules, and disturbances in organometric parameters were observed. The obtained data indicate a significant impact of rheumatoid arthritis on the condition of the reproductive system and suggest that the identified changes may represent one of the possible mechanisms of reduced male fertility in the context of chronic inflammatory processes.

Keywords: experimental rheumatoid arthritis; age-related changes; testes; organometric parameters.

First page

190

Last page

197

For citation:Teshaev Sh.J., Khabibullayev T.U. - AGE-RELATED MORPHOFUNCTIONAL ALTERATIONS IN TESTICULAR TISSUE OF OUTBRED WHITE RATS//New Day in Medicine 10(84)2025 190-197 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

List of References

1. Lin Ye, Hu Mingyue, Zhang Feng, Dai Zongshun, Xie Ying, Cai Xiong, Liu Liang, Systematic review of robust experimental models of rheumatoid arthritis for basic research,2021
2. María Eugenia Castañeda-Lopez, Idalia Garza-Veloz, José Manuel Ortiz-Rodriguez, Rodrigo Castañeda-Miranda, Animal Models of Rheumatoid Arthritis (chapter in Experimental Animal Models of Human Diseases, 2019
3. Carla Molthoff, Inge de Greeuw, Rolph van Kooij, Albert Windhorst, Adriaan Lammertsma, Conny van der Laken, An experimental rat model for PET studies of rheumatoid arthritis,2021

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