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  • 73 -10 (84) 2025 - Otakhanov B.R., Yuldashev B.S. - CHARACTERISTICS OF IMMUNOGISTOKHIMIChESKAYa ZLOKAChESTVENNYX OPUHOLEY KOSTNOY I TKANEVOY TKANEY V PRIARALBAYSKOM RAYONE

73 -10 (84) 2025 - Otakhanov B.R., Yuldashev B.S. - CHARACTERISTICS OF IMMUNOGISTOKHIMIChESKAYa ZLOKAChESTVENNYX OPUHOLEY KOSTNOY I TKANEVOY TKANEY V PRIARALBAYSKOM RAYONE

CHARACTERISTICS OF IMMUNOGISTOKHIMIChESKAYa ZLOKAChESTVENNYX OPUHOLEY KOSTNOY I TKANEVOY TKANEY V PRIARALBAYSKOM RAYONE

Otakhanov B.R. - Urgench branch of the Tashkent State Medical University

Yuldashev B.S. - "University Ma'muna"

Resume

This study presents an immunohistochemical analysis of malignant bone, cartilage, and soft tissue tumors - osteosarcoma, chondrosarcoma. A total of 60 cases (20 of each type) were examined using VEGF, Ki-67, and CD34 monoclonal antibodies immunoprocessor. The results demonstrated that osteosarcomas exhibited the highest vascular density (20 - 30 vessels per field), reflecting intense angiogenesis and strong VEGF/CD34 expression. The proliferative index Ki-67 was high in 70% of osteosarcoma cases, moderate (25%) in chondrosarcomas. These findings indicate that the immunohistochemical profile of VEGF, Ki-67, and CD34 can serve as valuable diagnostic and prognostic markers for assessing tumor aggressiveness and guiding therapeutic strategies.

Keywords: Osteosarcoma, chondrosarcoma, VEGF, Ki-67, CD34, angiogenesis, proliferation, immunohistochemistry, tumor aggressiveness.

First page

408

Last page

417

For citation:Otakhanov B.R., Yuldashev B.S. - CHARACTERISTICS OF IMMUNOGISTOKHIMIChESKAYa ZLOKAChESTVENNYX OPUHOLEY KOSTNOY I TKANEVOY TKANEY V PRIARALBAYSKOM RAYONE//New Day in Medicine 10(84)2025 408-417 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

List of References

  1. Худайкулова Ф. Х., Юлдашев Б. С. Колоректальный рак и его морфологические типы у населения, проживающего в неблагоприятной зоне ПРИАРАЛЬЯ //Журнал гуманитарных и естественных наук. 2024;17:278-284.
  2. Каипбергенов М. Б. Ретроспективный анализ частоты встречаемости онкологических заболеваний у населения ПРИАРАЛЬЯ // Фундаментальная наука и клиническая медицина. 2021; 462-463.
  3. Иванов А., Петров К. Иммуногистохимический анализ при саркомах. / Pathology Today, 2020.
  4. Рыбалкина Д. Х., Жанбасинова Н. М., Салимбаева Б. М. Онкологическая заболеваемость детей Приаралья // Bulletin of the Karaganda university Biology. Medicine. Geography series. 2017;85(1):75-79.
  5. Орынбасаров Серик Орынбасарович. Патоморфологическая характеристика легких, плаценты и их химический состав у плодов, новорожденных в перинатальном периоде в регионе Приаралья / Автореф. Дис… канд. Мед. Наук.-Новосибирск., 2015; 24 стр.
  6. Михалева Л. М. и др. Морфофункциональная характеристика кровеносных сосудов при доброкачественных и злокачественных гранулезо - клеточных опухолях яичников // Морфология. 2008;133(2):89-90.
  7. Буланов Дмитрий Владимирович. Актуальные аспекты патоморфологической диагностики опухолей семейства саркомы Юинга / Автореф. Дис… канд. Мед. Наук.- Волгоград., 2011; 24 с.
  8. Yoshida A. Ewing and Ewing-like sarcomas: A morphological guide through genetically-defined entities. // Pathol Int. 2023 Jan;73(1):12-26.
  9. Fletcher C.D.M. WHO Classification of Soft Tissue and Bone Tumours. 5th Edition, IARC, 2022.
  10. Wardelmann E, Hartmann W. Neues in der aktuellen WHO-Klassifikation (2020) für Weichgewebssarkome [New in the current WHO classification (2020) for soft tissue sarcomas]. Pathologe. 2021 May;42(3):281-293.
  11. Sakamoto N. et al. Angiogenesis and VEGF expression in soft tissue sarcomas. Modern Pathology, 2020.
  12. Machado I, Yoshida A, Morales MGN, Abrahão-Machado LF, Navarro S, Cruz J, Lavernia J, Parafioriti A, Picci P, Llombart-Bosch A. Review with novel markers facilitates precise categorization of 41 cases of diagnostically challeng-ing, "undifferentiated small round cell tumors". A clinicopathologic, immuno-phenotypic and molecular analysis. Ann Diagn Pathol. 2018 Jun;34:1-5.
  13. Mamyrbayev A, Djarkenov T, Dosbayev A, Dusembayeva N, Shpakov A, Umarova G, Drobchenko Y, Kunurkulzhayev T, Zhaylybaev M, Isayeva G. The Incidence of Malignant Tumors in Environmentally Disadvantaged Regions of Kazakhstan. Asian Pac J Cancer Prev. 2016 Dec 1;17(12):5203-5209.
  14. Mamyrbayev A, Djarkenov T, Dosbayev A, Dusembayeva N, Shpakov A, Umarova G, Drobchenko Y, Kunurkulzhayev T, Zhaylybaev M, Isayeva G. The Incidence of Malignant Tumors in Environmentally Disadvantaged Regions of Kazakhstan. Asian Pac J Cancer Prev. 2016 Dec 1;17(12):5203-5209.

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