80 -10 (84) 2025 - Rajapova G.F., Axmedjanova X.Z. - INFLUENCE OF COVID-19 INFECTION ON THE COURSE OF PREGNANCY AND PERINATAL OUTCOMES: TRIMESTER-SPECIFIC FEATURES AND PREVENTIVE APPROACHES

INFLUENCE OF COVID-19 INFECTION ON THE COURSE OF PREGNANCY AND PERINATAL OUTCOMES: TRIMESTER-SPECIFIC FEATURES AND PREVENTIVE APPROACHES

Rajapova G.F. - Tashkent State Medical University

Axmedjanova X.Z. - Tashkent State Medical University

Resume

Objective. To evaluate the impact of SARS-CoV-2 infection on the course of pregnancy and perinatal outcomes, taking into account trimester-specific features, and to determine the effectiveness of preventive approaches applied in obstetric practice in Uzbekistan. Materials and Methods. A systematic analysis of 86 scientific sources (PubMed, Scopus, Web of Science, eLibrary, UzMedline, 2020–2025) and national guidelines of the Ministry of Health of the Republic of Uzbekistan was conducted. The analysis covered immunological, hemostatic, echographic, and perinatal parameters. Results. In the first trimester, COVID-19 infection was associated with implantation disorders, cytokine imbalance (elevated IL-6, TNF-α), and an increased risk of early reproductive loss. In the second trimester, placental dysfunction and hypercoagulation predominated (1.5–2-fold increase in fibrinogen and D-dimer). In the third trimester, the incidence of gestosis and preterm birth increased (14.7 % vs. 6.8 %, p < 0.01). The use of low-molecular-weight heparins and antioxidant therapy reduced the risk of complications by 25–30 %. Implementation of telemedicine monitoring decreased hospitalizations by 32 % and improved early detection of fetal hypoxia. Conclusion. COVID-19 infection exerts trimester-specific effects on pregnancy and perinatal outcomes. A comprehensive approach — including anticoagulant prophylaxis, antioxidant support, telemedicine monitoring, and post-COVID rehabilitation — proved effective in reducing maternal and perinatal morbidity in the conditions of Uzbekistan.

Keywords: COVID-19, pregnancy, perinatal outcomes, placental dysfunction, preeclampsia, anticoagulant therapy, telemedicine.

First page

459

Last page

468

For citation:Rajapova G.F., Axmedjanova X.Z. - INFLUENCE OF COVID-19 INFECTION ON THE COURSE OF PREGNANCY AND PERINATAL OUTCOMES: TRIMESTER-SPECIFIC FEATURES AND PREVENTIVE APPROACHES//New Day in Medicine 10(84)2025 459-468 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

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