114 -10 (84) 2025 - Yuldasheva S.L. Khujamberdiev M.A. - A COMPREHENSIVE ASSESSMENT OF THE ACTIVITY OF THE SYMPATHOADRENAL SYSTEM AND THE IMMUNE RESPONSE IN POST-COVID RHEUMATOID ARTHRITIS

A COMPREHENSIVE ASSESSMENT OF THE ACTIVITY OF THE SYMPATHOADRENAL SYSTEM AND THE IMMUNE RESPONSE IN POST-COVID RHEUMATOID ARTHRITIS

Yuldasheva S.L. - Andijan State Medical Institute

Khujamberdiev M.A. - Andijan State Medical Institute

Uzbekova N.R. - Andijan State Medical Institute

Usmanova D.N. - Andijan State Medical Institute

Abdullaeva K.A. - Andijan State Medical Institute

Resume

At the end of 2020, SARS-CoV-2 (Severe Acute Respiratory coronavirus 2) infection, which caused the 2019 coronavirus disease (COVID-19) pandemic, affected more than 40 million people and led to more than 1.2 million deaths [1]. COVID-19 has posed a serious challenge to humanity. In the course of the development of the pandemic, a large number of new fundamental and medical problems have been revealed, and many common chronic non-communicable diseases, among which rheumatic and musculoskeletal diseases (RMSD) occupy one of the important positions [3], in the spectrum of which immunoinflammatory rheumatic diseases (RWRI) occupy a central place. MVRI are characterized by progressive pathology of joints, muscles, bones and internal organs, leading to disability, reduced quality of life and reduced life expectancy. The modern concept of the pathogenesis of COVID-19, which is based on the of a kind of virus-induced dysregulation (asynchronization) of innate and acquired immunity, leading to hyperproduction of a wide range of pro-inflammatory, anti-inflammatory, and immunoregulatory cytokines and other inflammatory mediators [6,7,8].

Key words: Cytokines, rheumatoid arthritis, COVID-19, autoimmune diseases, sympathoadrenal system.

First page

654

Last page

659

For citation:Yuldasheva S.L. Khujamberdiev M.A., Uzbekova N.R., Usmanova D.N., Abdullaeva K.A. - A COMPREHENSIVE ASSESSMENT OF THE ACTIVITY OF THE SYMPATHOADRENAL SYSTEM AND THE IMMUNE RESPONSE IN POST-COVID RHEUMATOID ARTHRITIS//New Day in Medicine 10(84)2025 654-659 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

List of References

1. Burbelo P.D., Iadarola M.J., Keller J.M., Warner B.M. Autoantibodies Targeting Intracellular and Extracellular Proteins in Autoimmunity // Front Immunol. 2021;8(12):48-49. doi: 10.3389/fimmu.2021.548469. eCollection 2021.
2. Cabrera Martimbianco A.L., Pacheco R.L., Bagattini A.M., Riera R. Frequency, signs and symptoms, and criteria adopted for long COVID-19 A systematic review. // Int. J. Clin. Pract. 2021;75(10):14357. doi: 10.1111/ijcp.14357
3. Calabrese L.H. Long COVID in inflammatory rheumatic diseases – What’s in a name? // Lancet Rheumatology. 2023;5(7):364-365. doi: 10.1016/S2665-9913(23)00134-0
4. De Stefano L., D’Onofrio B., Manzo A., Montecucco C., Bugatti S. The genetic, environmental, and immunopathological complexity of autoantibody-negative rheumatoid arthritis. // Int. J. Mol. Sci. -2021;22(22):123-186. doi: 10.3390/ijms222212386
5. Dewanjee S., Kandimalla R., Kalra R.S., Valupadas C., Vallamkon du J., Kolli V., COVID-19 and rheumatoid arthritis crosstalk: Emerging association, therapeutic options and challenges. // Cells. -2021;10(12):132-191. doi: 10.3390/cells10123291
6. Nasonov E., Samsonov M. The role of interleukin 6 inhibitors in therapy of severe COVID-19//Biomedical Pharmacotherapy. 2020; 131:123-125 doi: 10.1016/j.biopha.2020.110698
7. Nasonov E.L., Samsonov M.Y., Lila A.M. Coronavirus Infection 2019 (COVID-19) and Autoimmunity //Her. Russ. Acad. Sci.2022;92(4):398-403. DOI:10.1134/S1019331622040062
8. Parisi S., Borrelli R., Bianchi S., Fusaro E. Viral arthritis and COVID-19 // Lancet Rheumatology. 2020;2(11):655-657. doi: 10.1016/ S2665-9913(20)30348-9

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