119 -10 (84) 2025 - Akhmedova N.Sh., Zokhirova M.I. - MODERN PROBLEMS OF PATHOGENESIS AND EARLY DIAGNOSIS OF THE DEVELOPMENT OF ANEMIA IN CARDIORENAL SYNDROME (literature review)

MODERN PROBLEMS OF PATHOGENESIS AND EARLY DIAGNOSIS OF THE DEVELOPMENT OF ANEMIA IN CARDIORENAL SYNDROME (literature review)

Akhmedova N.Sh. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Zokhirova M.I. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

Cardiorenal syndrome (CRS) is a chronic dysfunction of the heart and kidneys, the clinical manifestation of which is anemia. CATTLE anemia worsens the prognosis, and hospitalization and treatment may be difficult. The pathogenesis of its development includes: inhibition of erythropoietin synthesis, inhibition of iron metabolism, inhibition of cytokine function, oxidative stress and neurohormonal dysregulation. Early diagnosis lacks abnormal biomarkers (creatinine, EGFR). Substitution markers (cystatin C, NGAL, KIM-1, hepcidin) can be selected as the starting ones for amino acid sequences. The article examines the pathogenetic mechanisms of anemia development in rats, its causes and consequences.

Key words: cardiorenal syndrome, anemia, pathogenesis, erythropoietin, hepcidin.

First page

682

Last page

686

For citation:Akhmedova N.Sh., Zokhirova M.I. - MODERN PROBLEMS OF PATHOGENESIS AND EARLY DIAGNOSIS OF THE DEVELOPMENT OF ANEMIA IN CARDIORENAL SYNDROME (literature review)//New Day in Medicine 10(84)2025 682-686 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

List of References

1. Silverberg, D. S., Wexler, D., Iaina, A. (2002). The role of anemia in the progression of congestive heart failure. New England Journal of Medicine, 2002;347(2):123-129.
2. McCullough, P. A., Ahmad, A., Tumlin, J. A. (2019). Anemia and the cardiorenal syndrome: current concepts and future directions. // Reviews in Cardiovascular Medicine 2002;20(2):63-72.
3. Eckardt K.U., Kurtz A. (2020). Regulation of erythropoietin production. // Journal of the American Society of Nephrology, 2020;31(2):225-239.
4. Weiss G., Goodnough, L.T. (2005). Anemia of chronic disease. // New England Journal of Medicine, 2005;352(10):1011-1023.
5. McDonagh, T. A., Metra, M., Adamo, M., et al. (2021). 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. // European Heart Journal, 2021;42(36):3599-3726.
6. McCullough, Peter A. “Anemia of cardiorenal syndrome.” // Kidney international supplements 2021;11(1):35-45. doi:10.1016/j.kisu.2020.12.001

   file

   download