142 -10 (84) 2025 - Boboeva О.F. - NEW MECHANISMS OF FORMATION OF METABOLIC SYNDROME IN ADOLESCENTS

NEW MECHANISMS OF FORMATION OF METABOLIC SYNDROME IN ADOLESCENTS

Boboeva О.F. - Bukhara State Medical Institute named after Abu Ali ibn Sina

Resume

The prevalence of MetS among youth is about 3–5% globally, but rises to 30% or more in obese adolescents. The pathophysiology of pediatric MetS centers on excess visceral fat and chronic low-grade inflammation leading to insulin resistance. Adipose-derived fatty acids and inflammatory cytokines impair insulin signaling, causing hyperinsulinemia and glucose intolerance, while also promoting atherogenic dyslipidemia (elevated triglycerides, low HDL) and elevated blood pressure. Key risk factors for MetS in adolescence include obesity – especially abdominal obesity – along with physical inactivity and poor diet. Genetic predisposition and family history of cardiometabolic diseases increase MetS susceptibility. Early identification of at-risk adolescents and multidisciplinary preventive strategies are crucial to mitigate the long-term health impact of metabolic syndrome in the young population.

Keywords: metabolic syndrome, adolescents, pathogenesis, insulin resistance

First page

809

Last page

814

For citation:Boboeva О.F. - NEW MECHANISMS OF FORMATION OF METABOLIC SYNDROME IN ADOLESCENTS//New Day in Medicine 10(84)2025 809-814 https://newdayworldmedicine.com/en/new_day_medicine/10-84-2025

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